Minimal change Glomerulonephritis

Question 1

What do you start for minimal change glomerulonephritis?

Answer 1

commence oral prednisolone

Question 2

What are the features of Minimal Change Disease?

Answer 2

nephrotic syndrome

normotension - hypertension is rare

highly selective proteinuria

only intermediate-sized proteins such as albumin and transferrin leak through the glomerulus

renal biopsy-

normal glomeruli on light microscopy

electron microscopy shows fusion of podocytes and effacement of foot processes

Question 3

Why is there low albumin level in Minimal Change Disease?

Answer 3

only intermediate-sized proteins such as albumin and transferrin leak through the glomerulus - hence there’s proteinuria and is classified as a nephrotic syndrome.

Question 4

What features would make you differentiate nephrotic and nephritic syndrome in relation to MCD?

Answer 4

MCD IS pure nephrotic syndrome with normotension.

IF the dipstick is positive for proteins BUT it is also highly positive for blood, IT INDICATES a nephritic syndrome.

Question 5

Minimal change glomerulonephritis first line

Answer 5

Prednisolone

Question 6

CHILDREN
proteinuria + Normotension + hypoalbuminemia =

Answer 6

Minimal change glomerulonephritis