Haemolytic uraemic syndrome- Renal/Paeds

Question 1

YOUNG CHILDREN

acute kidney injury + microangiopathic haemolytic anaemia + thrombocytopenia

Answer 1

Haemolytic uraemic syndrome

Question 2

best treatment for Haemolytic uraemic syndrome

Answer 2

supportive treatments - fluids and dialysis

Question 3

causative organismof HUS?

Answer 3

Escheria coli

Question 4

strain that causes HUS?

Answer 4

classically Shiga toxin-producing Escherichia coli (STEC) 0157:H7

Question 5

Investigation of HUS?

Answer 5

full blood count-
anaemia: microangiopathic hemolytic anaemia characterised by a haemoglobin level less than 8 g/dL with a negative Coomb’s test

thrombocytopenia

fragmented blood film: schistocytes and helmet cells

U&E: acute kidney injury-

stool culture-
looking for evidence of STEC infection
PCR for Shiga toxins