Acute Interstital Nephritis

Question 1

What drug causes Acute Interstitial Nephritis?

Answer 1

drugs: the most common cause, particularly antibiotics

penicillin
rifampicin
NSAIDs
allopurinol
furosemide

Question 2

What systematic diseases can cause Acute Interstitial Nephritis?

Answer 2

SLE, sarcoidosis, and Sjogren’s syndrome

Question 3

What are the features of Acute Interstitial Nephritis?

Answer 3

fever, rash, arthralgia (joint pain)
eosinophilia
mild renal impairment
hypertension

Question 4

What are the investigations of Acute Interstitial Nephritis?

Answer 4

sterile pyuria
white cell casts

Question 5

typically arises following drug therapy in the majority of cases + infections + systemic vasculitides forming the rest

Answer 5

Acute Interstitial Nephritis

Question 6

fever + arthralgia + maculopapular rash + mild renal impairment + eosinophilia

Answer 6

Acute Interstitial Nephritis

Question 7

What is Acute Interstitial Necrotitis

Answer 7

Acute interstitial nephritis (AIN) is characterized by the presence of inflammatory infiltrates and edema within the interstitium, usually associated with an acute deterioration in renal function.