Mini-Board 2012 Flashcards
Which caspase is activated during pyroptosis?
a. Caspase 1
b. Caspase 3
c. Caspase 6
d. Caspase 8
e. Caspase 9
A; VP 2011;48(5):933-‐41
Where is the majority of glutathione degraded?
a. Cytoplasm of hepatocytes
b. Cytoplasm of renal tubular epithelium
c. Brush border of distal convoluted tubules
d. Brush border of proximal convoluted tubules
e. Mitochondria of renal tubular epithelium
D; VP 2011;48(2):408-‐19
Which of the following complement regulatory proteins prevents formation of the membrane attack complex?
a. CR1
b. CRIg
c. DAF
d. Factor H
e. CD59
E; LI 2011;91:4-‐11
Which of the following toll-‐like receptors does NOT use MyD88 as its primary signaling molecule?
a. TLR1
b. TLR2
c. TLR3
d. TLR5
e. TLR9
C; NEJM 2011;364:60-‐70
Which of the following toll-‐like receptors is NOT found on the cell surface?
a. TLR2
b. TLR3
c. TLR5
d. TLR6
e. TLR11
B; NEJM 2011;364:60-‐70
During Mycobacterial infection in cattle, which of the following cytokines antagonizes the actions of TNF-‐α and IL-‐1β, thus potentiating the growth of the Mycobacteria?
a. IL-‐1α
b. IL-‐6
c. IL-‐10
d. IL-‐12
e. IFN-‐γ
B; VP 2012;49(3):428
In which of the following tissues is COX-‐2 NOT constitutively expressed?
a. Placenta
b. Cerebrum
c. Cerebellum
d. Heart
e. Kidney
D; VP 2011;48:254-‐265
Which statement is FALSE regarding prostaglandins?
a. High concentrations of PGE2 inhibit platelet aggregation
b. Low concentrations of PGE2 potentiate activation of platelets
c. PGE2 is related to myocardial hypertrophy
d. PGE2 is important during ischemic reperfusion
e. COX-‐2 inhibition reduces PGI2 and TXA2 levels
E; VP 2010;47:601-‐613
All of the following growth factors signal through receptors with intrinsic tyrosine kinase activity EXCEPT ___.
a. VEGF-‐A
b. IGF-‐1
c. FGF7
d. TGFα
e. BMP
E; VP 2010;47(1):77-‐97
Which of the following is NOT expressed by stem cells?
a. Oct-‐4
b. CD133
c. Connexin (GJIC)
d. CD44
e. CD99
C; VP 2009;46:819-‐835
