Mini-Board 2011 Flashcards
Pre-miRNA is processed to miRNA by which enzyme: A. RNA protease B. Dicer C. DNA protease D. mRNA ligase E. Donner
B – Dicer
The complement component binds to what portion of the B-cell receptor complex to generate Signal 2 which promotes B cell activation? A. CD 21 B. IgM C. CD 28 D. CD 4 E. CD 3
A – CD21
Which cytokines induce the proliferation of T-helper 17 (TH17) cells?
- IFN-gamma
- IL-4
- TGF-beta
- IL-6
- IL-12
A. 1 and 4 B. 1 and 3 C. 3 and 4 D. 2 and 3 E. 1 and 5
C – 3 and 4
Phosphorylation of RB protein is mediated by which complex? A. Cyclin B-CDK1 B. Cyclin A-CDK1 C. Cyclin A-CDK2 D. Cyclin E-CDK1 E. Cyclin D-CDK6
E – Cyclin D/CDK6
All are ligands for toll-like receptor 2 (TLR2) EXCEPT:
A. Zymosan B. Peptidoglycan C. Lipoarabinomannon D. Double-stranded RNA E. Phosphatidylinositol dimannoside
D – dsRNA
T lymphocyte anergy can be mediated by blocking IL-2 production when B7 is bound by which molecule?
A. CTLA-4 B. CD28 C. CD3 D. CCL2 E. SHPS-1
A – CTLA-4
Glanzmann’s thrombasthenia is caused by mutation of a Calcium- binding domain of:
A. GPIb B. GPIa C. GPIIb D. GPIIa E. GPIIIb
C – GPIIb
All are true for platlet activating factor (PAF) EXCEPT:
A. Produced by mast cells
B. Inhibited by PAF acetylhydrolase
C. Is a product of cycylooxygenase enzymes
D. Lysophosphatdylcholine is an intermediate form
E. Is derived from cytoplasmic phospholipase A2 activity
C – is a product of COX
Which increases in sepsis?
A. Plasminogen-activator inhibitor 1 B. Tissue factor-pathway inhibitor C. Antithrombin III D. Protein C E. Protein S
A – PAI-1
All of the following help induce endothelial proliferation except:
A. Hypoxia B. TGF-beta C. PDGF D. Endostatin E. TGF-alpha
D – endostatin
Which of the following point within the cell cycle is responsible for monitoring the integrity of DNA prior to replication:
A. G0 phase B. G1/S checkpoint C. G2 D. G2/M checkpoint E. M phase
B – G1/S checkpoint
Basophils lack which of the following:
A. Heparin B. Histamine C. LTC4 D. LTD4 E. LTE4
A – heparin
All of the following are true concerning Delta-like ligand 4, EXCEPT:
A. It is expressed in arteries B. It is expressed in capillaries C. It is expressed in veins D. It interacts with NOTCH E. Blockade of Delta-like ligand 4 results in increased vessel sprouting
C – expressed in veins
The alternative pathway within the complement cascade is activated by: A. IgG B. IgM C. IgE D. Mannose-binding lectin E. LPS
E – LPS
Gradual cooling of the cadaver is referred to as:
A. Livor mortis B. Algor mortis C. Rigor mortis D. Softening E. Anthropogenic cooling
B – algor mortis
Antithrombin III degrades all of the following activated coagulation factors except:
A. Factor X B. Factor XII C. Factor II D. Factor VII E. Factor III
D – Factor VII
All of the following are proapoptotic except:
A. Cytochrome c B. Tumor Necrosis Factor (TNF) C. Mcl-1 D. Bax E. Bak
C – Mcl-1
Which of the following is classified as a CX3C chemokine?
A. Lymphotactin B. Fractalkine C. Eotaxin D. RANTES E. Monocyte chemoattractant protein (MCP-1)
B – fractalkine
Which of the following tissues does not have fenestrated capillaries?
A. Liver B. Intestinal villi C. Choroid plexus D. Ciliary body E. Glomeruli
A – liver
Which of the following coagulation factors is not part of the interdependent contact group?
A. Factor IX B. Factor XI C. Factor XII D. Prekallikrein E. HMWK
A – Factor IX
Platelet binding to which of the following forms the strongest bond?
A. Collagen B. GpIb/VWF C. Fibronectin D. Glycoprotein E. Proteoglycan
B – GpIb/vWF
Cytokines produced by tumor-infiltrating immune cells predominately activate which of the following key transcriptions factors: A. c-Myc B. Bcl-6 C. STAT3 D. STAT5 E. l-Myc
C – STAT3
The inflammasome’s primary role involves cytokine processing and regulation of inflammation via cleavage and activation of which of the following:
A. IL-3 and IL-15 B. IL-1C and IL-22 C. IL-1B and IL-18 D. IL-3 and IL- 6 E. IL-4 and IL-10
C – IL-1B and IL-18
All TLR family members use the MYD88 EXCEPT:
A. TLR5 B. TLR3 C. TLR9 D. TLR7 E. TLR4
B – TLR3
All of the following are surface molecules present on naïve B lymphocytes EXCEPT:
A. IgM B. IgD C. CD21 D. CD40 E. CD28
E – CD28
All of the following statements are true regarding natural killer cells EXCEPT:
A. They are active in antibody dependent cell-mediated cytotoxicity (ADCC)
B. Natural killer cells require exposure to antigen via MHC II molecules
C. CD 16 and CD 56 are two of the cell surface molecules
D. They are also know as large granular lymphocytes because of their abundant azurophilic granules
E. Natural killer cells are important in defense against tumor cells
B
Which caspase is activated by the Fas-associated death domain?
A. Caspase 3 B. Caspase 6 C. Caspase 8 D. Caspase 9 E. Caspase 10
C – caspase 8
