Mini-Board 2011

Question 1

Pre-miRNA is processed to miRNA by which enzyme:
A. RNA protease
B. Dicer
C. DNA protease
D. mRNA ligase
E. Donner

Answer 1

B – Dicer

Question 2

The complement component binds to what portion of the B-cell receptor complex to generate Signal 2 which
promotes B cell activation?
A. CD 21
B. IgM
C. CD 28
D. CD 4
E. CD 3

Answer 2

A – CD21

Question 3

Which cytokines induce the proliferation of T-helper 17 (TH17) cells?

1. IFN-gamma
2. IL-4
3. TGF-beta
4. IL-6
5. IL-12

A. 1 and 4
B. 1 and 3
C. 3 and 4
D. 2 and 3
E. 1 and 5

Answer 3

C – 3 and 4

Question 4

Phosphorylation of RB protein is mediated by which complex?
A. Cyclin B-CDK1
B. Cyclin A-CDK1
C. Cyclin A-CDK2
D. Cyclin E-CDK1
E. Cyclin D-CDK6

Answer 4

E – Cyclin D/CDK6

Question 5

All are ligands for toll-like receptor 2 (TLR2) EXCEPT:

A. Zymosan
B. Peptidoglycan
C. Lipoarabinomannon
D. Double-stranded RNA
E. Phosphatidylinositol dimannoside

Answer 5

D – dsRNA

Question 6

T lymphocyte anergy can be mediated by blocking IL-2 production when B7 is bound by which molecule?

A. CTLA-4
B. CD28
C. CD3
D. CCL2
E. SHPS-1

Answer 6

A – CTLA-4

Question 7

Glanzmann’s thrombasthenia is caused by mutation of a Calcium- binding domain of:

A. GPIb
B. GPIa
C. GPIIb
D. GPIIa
E. GPIIIb

Answer 7

C – GPIIb

Question 8

All are true for platlet activating factor (PAF) EXCEPT:

A. Produced by mast cells
B. Inhibited by PAF acetylhydrolase
C. Is a product of cycylooxygenase enzymes
D. Lysophosphatdylcholine is an intermediate form
E. Is derived from cytoplasmic phospholipase A2 activity

Answer 8

C – is a product of COX

Question 9

Which increases in sepsis?

A. Plasminogen-activator inhibitor 1
B. Tissue factor-pathway inhibitor
C. Antithrombin III
D. Protein C
E. Protein S

Answer 9

A – PAI-1

Question 10

All of the following help induce endothelial proliferation except:

A. Hypoxia
B. TGF-beta
C. PDGF
D. Endostatin
E. TGF-alpha

Answer 10

D – endostatin

Question 11

Which of the following point within the cell cycle is responsible for monitoring the integrity of DNA prior to replication:

A. G0 phase
B. G1/S checkpoint
C. G2
D. G2/M checkpoint
E. M phase

Answer 11

B – G1/S checkpoint

Question 12

Basophils lack which of the following:

A. Heparin
B. Histamine
C. LTC4
D. LTD4
E. LTE4

Answer 12

A – heparin

Question 13

All of the following are true concerning Delta-like ligand 4, EXCEPT:

A. It is expressed in arteries
B. It is expressed in capillaries
C. It is expressed in veins
D. It interacts with NOTCH
E. Blockade of Delta-like ligand 4 results in increased vessel sprouting

Answer 13

C – expressed in veins

Question 14

The alternative pathway within the complement cascade is activated by:
A. IgG
B. IgM
C. IgE
D. Mannose-binding lectin
E. LPS

Answer 14

E – LPS

Question 15

Gradual cooling of the cadaver is referred to as:

A. Livor mortis
B. Algor mortis
C. Rigor mortis
D. Softening
E. Anthropogenic cooling

Answer 15

B – algor mortis

Question 16

Antithrombin III degrades all of the following activated coagulation factors except:

A. Factor X
B. Factor XII
C. Factor II
D. Factor VII
E. Factor III

Answer 16

D – Factor VII

Question 17

All of the following are proapoptotic except:

A. Cytochrome c
B. Tumor Necrosis Factor (TNF)
C. Mcl-1
D. Bax
E. Bak

Answer 17

C – Mcl-1

Question 18

Which of the following is classified as a CX3C chemokine?

A. Lymphotactin
B. Fractalkine
C. Eotaxin
D. RANTES
E. Monocyte chemoattractant protein (MCP-1)

Answer 18

B – fractalkine

Question 19

Which of the following tissues does not have fenestrated capillaries?

A. Liver
B. Intestinal villi
C. Choroid plexus
D. Ciliary body
E. Glomeruli

Answer 19

A – liver

Question 20

Which of the following coagulation factors is not part of the interdependent contact group?

A. Factor IX
B. Factor XI
C. Factor XII
D. Prekallikrein
E. HMWK

Answer 20

A – Factor IX

Question 21

Platelet binding to which of the following forms the strongest bond?

A. Collagen
B. GpIb/VWF
C. Fibronectin
D. Glycoprotein
E. Proteoglycan

Answer 21

B – GpIb/vWF

Question 22

Cytokines produced by tumor-infiltrating immune cells predominately activate which of the following key transcriptions factors:
A. c-Myc
B. Bcl-6
C. STAT3
D. STAT5
E. l-Myc

Answer 22

C – STAT3

Question 23

The inflammasome’s primary role involves cytokine processing and regulation of inflammation via cleavage and activation of which of the following:

A. IL-3 and IL-15
B. IL-1C and IL-22
C. IL-1B and IL-18
D. IL-3 and IL- 6
E. IL-4 and IL-10

Answer 23

C – IL-1B and IL-18

Question 24

All TLR family members use the MYD88 EXCEPT:

A. TLR5
B. TLR3
C. TLR9
D. TLR7
E. TLR4

Answer 24

B – TLR3

Question 25

All of the following are surface molecules present on naïve B lymphocytes EXCEPT:

A. IgM
B. IgD
C. CD21
D. CD40
E. CD28

Answer 25

E – CD28

Question 26

All of the following statements are true regarding natural killer cells EXCEPT:
A. They are active in antibody dependent cell-mediated cytotoxicity (ADCC)
B. Natural killer cells require exposure to antigen via MHC II molecules
C. CD 16 and CD 56 are two of the cell surface molecules
D. They are also know as large granular lymphocytes because of their abundant azurophilic granules
E. Natural killer cells are important in defense against tumor cells

Answer 26

B

Question 27

Which caspase is activated by the Fas-associated death domain?

A. Caspase 3
B. Caspase 6
C. Caspase 8
D. Caspase 9
E. Caspase 10

Answer 27

C – caspase 8