Minerals Metabolism Flashcards

0
Q

Minerals description

A

Inorganic compounds
No carbon structure
Non caloric
Remain ash when completely burnt

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1
Q

Left when the body decays?

A

5 pounds of minerals

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2
Q

Major electrolytes for avid base balance?

A

PISO - cation

BICO - anion

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3
Q

Left when the body decays?

A

5 pounds of minerals

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4
Q

Cations or positive charge

A

Calcium
Magnesium
Sodium
Potassium

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5
Q

Anions or negative charge

A

Chloride
Sulfate
Phosphorus

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6
Q

Major cation of macro

A

Calcium

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7
Q

Major anion of macro

A

Phosphorus

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8
Q

Kaya ibalance ng katawan ang level ng excretion at absorption

A

Essential minerals

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9
Q

Hindi kayang i balance

A

Non essential minerals

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10
Q

Amount of mineral that is capable of entering the circulation available for metabolic usage

A

Mineral biovailability

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11
Q

Different factor affect the bio availability

A

Physiologic need on the time of consumption
Minerals to minerals interaction
Fiber mineral interaction
Vitamin mineral interaction

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12
Q

Example of physiologic need on the time of consumption

A

Iron on IDA

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13
Q

Example of minerals to minerals interaction

A

Copper and zinc

Zinc and iron

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14
Q

Copper and zinc, compete in the same

A

Binding protein, melanothionine

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15
Q

Zinc and iron compete in

A

Transport protein, transferrin

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16
Q

Example of fiber mineral interaction

A

Fiber and iron, hindi mo coconvert si ferric to become ferrous dahil iinhibit ni ni fiber si ferric reductase dahil sa fitic acid

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17
Q

Example of vitamin mineral interaction

A

Vit. C and Iron,

Increase the absorption of Iron

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18
Q

The most biochemical function of your mineral?

A

Co factor in catalytic activity

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19
Q

Co factor of amylase

A

Chloride

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20
Q

Co factor of anhydrase

A

Zinc

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21
Q

Co factor of citopherol from ETC

A

Copper and iron

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22
Q

Apo enzyme is specific and tightly bound to the enzyme

A

Metallo enzyme

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23
Q

Not specific and loosely bound to the enzyme

A

Non metalloenzyme

Kapag sinabi natin na specific at tight, kapag nawala na si mieral wala naring silbi si enzyme

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24
Ferric
Oxidized Transport Bind with transferrin
25
Ferrous
Reduced | Absorbable
26
Iron will help in oxygen transport
Hemew
27
Function of iron
Heme ETC Enhance brain function/ myelination Immune response
28
Iron enhance immune response, it is co factor of enzyme? That enhance the activity of?
Myeloperoxidase | Neutrophil
29
Two forms of Iron
Heme- from animal | Nonheme- from plant
30
The most component of your heme is.
Ferrous
31
Carry the heme
Heme carrier protein 1
32
Main ionic state of non heme is
Ferric, it should be reduced bythe used of enzyme ferric reductase or duodenal cythochrome
33
Ferrous from non heme will then enter the enterocyte via?
DMT1
34
To release ferrous from heme we need?
Heme oxygenase
35
So meron ng ferrous from heme and non heme, kapag marami ng masyadong ferrous ano na mangyayari?
Hindi na sya maabsorb at pupunta ito sa liver as part of liver iron pool
36
Ferrous will be stored in the liver in the form of
Ferritin
37
Mababa ang iron sa blood, kailangang i absorb si ferrous. Who carry ferrous into the blood?
FPN for absorption | Ferrin for transport
38
Co factor of ferrous oxidase | Co factor of ferric reductase
Copper | Vitamin C
39
Saan ng galing si copper na co factor ng ferrous oxidase?
Hepheistin
40
How can i stop iron absorption?
Stop mo si FPN, diba nga sya yung nag aAbsorb. Pero ang master regulation ng absorption ay si HEPTIDIN. Increase HEPTIDIN, decrease FPN
41
Kailan iniinom ang IRON
Kapag mataas ang acid sa katawan, hwag isabay sa milk, tea, coffe at fiber
42
Bakit may IDA wala namang bleeding?
Increase inflammatory mediator will increase heptidin will decrease FPN will decrease IRON
43
Heptidin
25 AA | Being encoded by your Hamp gene
44
Function of zinc
``` Spermatogenesis Insulin activity GIT problems of pedia Anti oxidant PMS Lower prostate cancer Co factors ```
45
Anti oxidant mineral which include ZINC, COPPER, MANGANESE through what emzyme?
Superoxide dismutase
46
Anti oxidant selenium with enzyme
Glutathione peroxidase
47
Zinc as co factor to enzymes
``` Carbonic anhydrase Peptidase Thimidine kinase Lactate dehydrogenase Alkaline phosphatase Alcohol dehydrogenase Superoxide dismutase ```
48
How to control zinc in the body?
Plama membrane DIP transporter | Betazone ZIP transporter
49
Autosomal recessive disorder, HZ4 undergo mutation
Acrodermatitis entero hepatica
50
Absorb zinc, kapag mutated no absorption
Human zinc 4
51
Function of copper
Co factor for oxydation of iron Anti oxidant Cofactor of collagen synthesis Co factor on melanin production
52
Copper as oxydation of IRON
Ferrous oxidase
53
Opper as anti oxidant
Superoxide dismutase
54
Copper as co factor on collagen metabolism
Lysl oxidase
55
Copper aso co factor on melanin production
Tyroxidase
56
From membrane to liver who carry copper?
HCTR1
57
Copper chaperon
COX17 CTS Glutathione ATOPS1
58
Magdadala kay copper sa mitochondria
COX 17
59
Copper as co factor in ETC
Cytochrome oxidase
60
Dadalin nya si copper papuntang cytosol to be use by superoxide dismutase
CTS
61
Sa bindin prtein nya dadalhin, metalothionine
Glutathione
62
Dadalhin nya s a golgi apparatus
ATOPS1
63
ATP 7B gene mutation, toxicity of copper
Wilson disease
64
Saan na sstore si copper maliban sa liver?
Cornea, desment membrane
65
Para mabawasan ang copper toxicity
Phencilamin
66
Kapag sa brain naman nag accumulate si Copper
ATP 7A gene mutation, Menke's disease X linked disorder
67
Function of manganese
For testis Co factor for pyruvate carboxylase Collagen metabolism Involved in cholesterol metabolism
68
Manganese as co factor for pyruvate carboxylase
Gluconeogenesis
69
Manganes as co factor in urea cycle
Arginase
70
Manganese as co factor in detoxification of ammonia
Glutamine synthetase
71
Manganese as cofactor on organic matrix
Glycosyl transferase
72
Manganese involved in collagen metabolism
Prolipase
73
Manganese involved in cholesterol metabolismqq
Glycocilation reaction
74
Iodine ATP production
Glycolysis Kreb ETC Beta oxidation
75
End product of lipolysis
3 fatty acid and glycerol
76
Selenium transport
Passive diffusion transport | Lipoprotein if goes to circulation
77
Selenium excreted through
Urine
78
Selenium def
Cardiac- kenshan disease - female chinese Arthritis- kanshenbets disease
79
What are the different mineral that affect T3 and T4
Iodine and selenium