Migraines (Exam #2) Flashcards
What is the DOC for migraines, and what is its MOA?
Sumatriptan (Imitrex)
- 5-HT1D agonist
Which medication has an MOA of 5-HT1D agonist, and what is its primary use?
Sumatriptan (Imitrex)
- DOC for migraines
Generally, what are the AEs and CIs of Sumatriptan (Imitrex) based on?
VASOCONSTRICTION
How does Ergotamine (Ergomar) differ from Sumatriptan (Imitrex) in terms of MOA (2)?
Both are 5-HT receptor agonists but…
- Ergotamine is LESS specific (Sumatriptan is 5-HT1D only)
- Ergotamine also acts on alpha1 receptors
Is Ergotamine (Ergomar) or Sumatriptan (Imitrex) more potent? How does this effect MOAs?
Ergotamine (Ergomar) = MORE vasoconstriction
- More AEs
What is ergotism, and what medication is it associated with?
Ergotamine (Ergomar)
- Chronic vasoconstriction + CNS sxs
What is the primary AE associated with Dihydroergotamine (Migranal)?
Nausea
What four medications can be used to treat acute migraine pain?
- ASA
- Acetaminophen
- Naproxen
- Propoxyphene
What medication should be avoided in tx of acute migraines?
NO OPIOIDS
What five CV meds can be used to tx migraine prophylaxis?
- BB (Propranolol)
- CCB (Verapamil)
- Clonidine
- ACE-I
- ARBs
What two anticonvulsants can be used to tx migraine prophylaxis?
- Valproic Acid
- Topiramate (Topomax)
What two antidepressants can be used to tx migraine prophylaxis??
- Amitriptyline
- Fluoxetine
What is the MOA of Erenumab (Aimovig), and what is its primary use?
IgG2 monoclonal Ab
- Migraine prophylaxis
What migraine prophylaxis medication is an IgG2 monoclonal Ab that binds CGRP?
Erenumab (Aimovig)
