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joeli unit 3 > migraine > Flashcards

migraine Flashcards

1
Q

what structures play a role in migraine

A

cortex
hypothalamus
upper cervical spinal cord
medulla
pons

thalamus

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2
Q

where is the trigeminocervical nucleus found

A

medulla
upper cervical spinal cord

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3
Q

what converges at the trigeminocervical nucleus

A

trigeminal afferent
C1-C3 afferent

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4
Q

path from trigeminocervical nucleus

A

trigeminocervical nucleus –> trigeminothalamic tract –> thalamus

explains why you have NECK PAIN

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5
Q

sterile inflammation activates meningeal receptors on what cranial nerve

A

CN5 (trigeminal)

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6
Q

what 2 structures receive info from CN5 and exert a PARASYMPATHETIC effect on vessels causing vasodilation

A

superior salivatory nucleus (SSN)
pterygopalatine ganglion

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7
Q

the involvement of what structure could explain anxiety/depression in migraine sufferers

A

raphe nucleus

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8
Q

the involvement of what structure could explain difficulty sleeping/sleep changes in migraine sufferers

A

locus coeruleus

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9
Q

the involvement of what structure explains the lack of appetite in migraine sufferers

A

hypothalamus

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10
Q

the involvement of what structure explains nausea and vomiting in migraine sufferers

A

CTZ

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11
Q

alterations in peripheral nociceptors that changed them from high threshold to low threshold sensory neurons

A

peripheral sensitization

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12
Q

intracranial hypersensitivity is caused by

A

peripheral sensitization

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13
Q

what type of sensitization is responsible for throbbing sensation in migraines

A

peripheral sensitization

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14
Q

second-order neurons in the trigeminocervical complex become hyperexcitable

A

central sensitization

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15
Q

extracranial hypersensitivity is caused by

A

central sensitization

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16
Q

what is responsible for allodynia

A

central sensitization

17
Q

what is responsible for neck stiffness

A

central sensitization

18
Q

cortical spreading depression activates

A

nociceptive receptors in CN5

19
Q

what population of people is most likely to suffer from migraines

A

females

20
Q

what does COMT break down

A

epinephrine

21
Q

what does estrogen modulate

A

COMT

22
Q

increased estrogen leads to

A

decreased COMT –> increased epinephrine

joeli unit 3 (7 decks)

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