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PMQA > [MIDTERMS] PMQA LAB : Exercise 07 - Mineral Oil Emulsion > Flashcards

[MIDTERMS] PMQA LAB : Exercise 07 - Mineral Oil Emulsion Flashcards

1
Q

Raw Materials of Mineral Oil Emulsion

A
  1. Mineral Oil
  2. Acacia
  3. Syrup
  4. Vanillin
  5. Alcohol
  6. Purified Water
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2
Q

Active Ingredient (Laxative)

A

Mineral Oil

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3
Q

Emulsifying Agent

A

Acacia

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4
Q

Sweetener

A

Syrup

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5
Q

Flavorant

A

Vanillin

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6
Q

Co-Solvent, Stabilizer

A

Alcohol

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7
Q

Vehicle

A

Purified Water

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8
Q

Raw Materials of Mineral Oil Emulsion

A
  1. Mineral Oil
  2. Acacia
  3. Syrup
  4. Vanillin
  5. Alcohol
  6. Purified Water
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9
Q

Active Ingredient (Laxative)

A

Mineral Oil

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10
Q

Emulsifying Agent

A

Acacia

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11
Q

A dispersed system in which the dispersed phase is composed of small globules of liquid distributed throughout the vehicle in which it is immiscible.

A

Emulsion

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12
Q

Particle Size of Emulsion

A

0.1 to 100 microns

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13
Q

Purposes of Formulating an Emulsion

A

• Increased Drug Solubility
• Prolonged Drug Action
• Improved Taste
• Improved Appearance

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14
Q

Two (2) Phases of Emulsion

A
  1. Disperse Phase
  2. Dispersion Medium
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15
Q

It is the undissolve or immiscible drug distributed throughout the liquid vehicle.

A

Disperse Phase

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16
Q

It is the liquid vehicle, to which the insoluble drug is distributed.

A

Dispersion Medium

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17
Q

Three (3) Factors that Determine the Emulsion Type

A
  1. Emulsifier
  2. Phase Ratio
  3. Order or Mixing
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18
Q

Four (4) Types of Emulsion

A
  1. Oil-In-Water
  2. Water-In-Oil
  3. Microemulsion
  4. Multiple Emulsions
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19
Q

An emulsion type where oil is dispersed as droplets in an aqueous medium.

A

Oil-In-Water

20
Q

An emulsion type where water is dispersed in an oil or oleaginous medium.

A

Water-In-Oil

21
Q

An emulsion type where it appears translucent or transparent and have droplet diameter in nanometer size range.

A

Microemulsion

22
Q

It is molecule which has two parts, one is hydrophilic and the other is hydrophobic. Upon the addition of SAA, it tends to form monolayer film at the oil-in-water interface.

A

Emulsifying Agents

23
Q

(T/F): Emulsifying Agents are the same as Surface Active Agent (SAA).

A

T

24
Q

Three (3) Types of Emulsifying Agents

A
  1. Natural Sources
  2. Finely Divided Solids
  3. Synthetic Emulsifying Agents
25
Q

Example/s of Natural Emulsifying Agents

A

• Acacia
• Tragacanth
• Pectin
• Derivative of Cellulose
• Gelatin, Cholesterol, and Wool Fat

26
Q

Example/s of Finely Divided Solids used as Emulsifying Agents

A

• Bentonite
• Veegum
• Magnesium Hydroxide
• Aluminum Hydroxide
• Magnesium Trisilicate

27
Q

Three (3) Example/s of Synthetic Emulsifying Agents

A
  1. Cationic Surfactants
  2. Anionic Surfactants
  3. Non-Ionic Surfactants
28
Q

A synthetic surfactant that has marked antibacterial and anti-infective properties (e.g., quaternary ammonium compounds).

A

Cationic Surfactants

29
Q

A synthetic surfactant that forms oil-in-water emulsions (e.g., alkali soaps).

A

Anionic Surfactants

30
Q

(T/F): Spans and Tweens are examples of Non-Ionic Surfactants.

A

T

31
Q

Four (4) Methods of Preparation of Emulsions

A
  1. Wet Gum Method
  2. Dry Gum Method
  3. Bottle Method
  4. Nascent Soap Method
32
Q

Four (4) Identification Tests for Emulsions

A
  1. Miscibility Test
  2. Fluorescence Test
  3. Conductivity Test
  4. Dye Solubility Test
33
Q

Test that uses oil-in-water emulsion can be diluted with water and water-in-oil emulsion with oil. When oil is added to an oil-in-water emulsion or water to water-in-oil emulsion, the additive is not incorporated into the emulsion and separation is apparent.

A

Miscibility Test

34
Q

Test that uses oils give fluorescence under UV light, while water doesn’t.

A

Fluorescence Test

35
Q

Test when pair of electrons connected to the lamp and an electrical source is dipped into an oil-in-water emulsion, the lamp lights because of the passage of current between the two electrodes. If the lamp doesn’t light, it is assumed that the system is water-in-oil.

A

Conductivity Test

36
Q

Test where water soluble dye will dissolve in the aqueous phase of an emulsion while an oil soluble dye will be taken up by the oil phase.

A

Dye Solubility Test

37
Q

Test where an emulsion is added to dried filter paper soaked in cobalt chloride solution, it turns from blue to pink indicating that the emulsion is oil-in-water type.

A

Cobalt Chloride Test

38
Q

Six (6) Problems in Emulsions

A
  1. Creaming
  2. Cracking
  3. Aggregation
  4. Coalescence
  5. Sedimentation
  6. Phase Inversion
39
Q

Problem that refers to the separation of the concentrated emulsified droplets form the continuous phase.

A

Creaming

40
Q

Problem causing total separation of the two phases.

A

Cracking

41
Q

Problem where globules come together but do not fuse.

A

Aggregation

42
Q

Problem where globules come together and fuse.

A

Coalescence

43
Q

Problem that is the reverse of creaming.

A

Sedimentation

44
Q

Six (6) Problems in Emulsions

A
  1. Creaming
  2. Cracking
  3. Aggregation
  4. Coalescence
  5. Sedimentation
  6. Phase Inversion
45
Q

Problem that refers to the separation of the concentrated emulsified droplets form the continuous phase.

A

Creaming

PMQA (9 decks)

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