MIDTERM 01 - Local Anti-infectives Flashcards
He discovered carbolic acid (phenol) in 1867; he is considered as the “father of antiseptic surgery”
Joseph Lister
He created antibacterial dyes and antiparasitic organic arsenicals; he also created salvarsan, which is used to treat syphilis; he is considered as the “father of chemotherapy”
Paul Ehrlich
Paul Ehrlich proposed the principle of __________, which refers to the property of certain chemicals to kill one type of organism while not harming another
Selective toxicity
Year when antimicrobial agents were first used
1920s
Anti-infective agents were based on the group-IIB element __________ and group-VA elements __________ and __________ (MAA)
Mercury, Arsenic, Antimony
Year when sulfonamides and sulfones were first used
1950s
Are anti-infective agents that are used locally
Germicides
Are compounds that kill or prevent the growth of microorganisms when applied to living tissue (Subtypes of germicides)
Antiseptics
Are agents that prevent transmission of infection by the destruction of pathogenic microorganisms when applied to inanimate objects (Subtypes of germicides)
Disinfectants
The most important means of preventing transmission
Handwashing
Application of an agent to living tissue for the purpose of preventing infection (Standards for removing microorganisms)
Antisepsis
Destruction or marked reduction in the number or activity of microorganisms (Standards for removing microorganisms)
Decontamination
Chemical or physical treatment that destroys most vegetative microbes or viruses, but not spores, in or on inanimate surfaces (Standards for removing microorganisms)
Disinfection
Reduction of microbial load on an inanimate surface to a level considered acceptable for public health purposes (Standards for removing microorganisms)
Sanitization
A process intended to kill or remove all types of microorganisms, including spores, and usually including viruses with an acceptably low probability of survival (Standards for removing microorganisms)
Sterilization
A process that kill nonsporulating microorganisms by hot water or steam at 65°C-100°C (Standards for removing microorganisms)
Pasteurization
Activity __________ with molecular weight (SAR of primary alcohols against S. aureus)
Increases
As chain length __________, van der Waals interactions increase, and the ability to penetrate microbial membranes increases (SAR of primary alcohols against S. aureus)
Increases
As water solubility __________, the apparent antimicrobial potency diminishes (SAR of primary alcohols against S. aureus)
Decreases
Branching of the alcohol chain __________ antibacterial property (SAR of primary alcohols against S. aureus)
Decreases
Mechanism of action for primary alcohols
Protein and carbohydrate denaturation
Ranking of alcohols according to activity
Primary > Secondary > Tertiary
A product of fermentation from grains and many other carbohydrates; by hydration of ethylene (Alcohol and related compounds)
Ethanol (Ethyl alcohol, Wine spirit)
Is ethanol that has been rendered unfit for use in intoxicating beverages by the addition of other substances (Alcohol and related compounds)
Denatured alcohol (Methylated spirits, Denatured rectified spirit)
Contains added wood alcohol (methanol) and benzene and is unsuitable for either internal or external use (Alcohol and related compounds - denatured alcohol)
Completely denatured alcohol
Is ethanol treated with one or more substances so that its use may be permitted for a specialized purpose (Alcohol and related compounds - denatured alcohol)
Specially denatured alcohol
__________ is externally used as an antiseptic, preservative, and mild counterirritant
Alcohol
__________ is used as an astringent, rubefacient, and mild local anesthetic
Rubbing alcohol
__________ is injected near nerves and ganglia to alleviate pain; has a low narcotic potency and is used internally in diluted form as a mild sedative
Ethanol
Uses ethanol as sole solvent (Examples of alcohol preparations)
Spirits
Uses water and ethanol as solvent (Examples of alcohol preparations)
Tinctures
Uses ethanol as cosolvent (Examples of alcohol preparations)
Fluidextracts
Drug that inhibits aldehyde dehydrogenase; used to treat alcoholism
Disulfiram (Antabuse)
Contains NLT 99% w/w C2H5OH; used as a chemical reagent or solvent; is not ingested (Alcohol and related compounds)
Dehydrated alcohol (Absolute ethanol)
Considered as a suitable substitute for ethanol; used as antiseptic for the skin and disinfectant for surgical instruments (Alcohol and related compounds)
Isopropyl alcohol
_________% concentration is considered equal in antiseptic efficacy to a 60% ethanol in water solution
40%
Used to sterilize medical equipment and certain pharmaceuticals that cannot be heat-sterilized in an autoclave (Alcohol and related compounds)
Ethylene oxide (C2H4O)
Ethylene oxide forms explosive mixtures in air at concentrations ranging from __________ to __________ by volume
3%-80%
A commercial sterilant containing 10% ethylene oxide and 90% carbon dioxide by volume
Carboxide
Is irritating to mucous membranes, causes hardening of the skin, and is carcinogenic (Aldehyde compounds)
Formaldehyde (Formalin)
Formalin contains NLT __________% w/v of formaldehyde
37%
Is used as a dilute solution for sterilization of equipment and instruments that cannot be autoclaved; is stabilized in alkaline solution (Aldehyde compounds)
Glutaraldehyde
Remains the standard to which the activity of most germicidal substances is compared
Phenol, USP
The ratio of a dilution of a given test disinfectant to the dilution of phenol that is required to kill a strain of Salmonella typhi under carefully controlled time and temperature conditions
Phenolic coefficient
Substitution of alkyl, aryl, and halogen (especially in the __________ position) increases bactericidal activity (SAR of phenol)
Para
Substitution with alkyl, aryl, and halogen (especially in the para position) groups __________ bactericidal activity (SAR of phenol)
Increases
Straight-chain alkyl groups __________ bactericidal activity more than branched groups (SAR of phenol)
Enhance
Alkylated phenols and resorcinols are __________ toxic than the parent compounds while retaining bactericidal properties (SAR of phenol)
Less
Phenols denature bacterial proteins at __________ concentrations (SAR of phenol)
Low
Lysis of bacterial cell membranes with phenols occur at __________ concentrations (SAR of phenol)
Higher
Considered as a protoplasmic poison (caustic to the skin); is used occasionally as an antipruritic in phenolated calamine lotion (Phenols and their derivatives)
Phenol/Carbolic acid
Is simply phenol containing 10% water; the liquid form is convenient because it can be measured and transferred easily (Phenols and their derivatives)
Liquefied phenol
Used in combination with camphor in liquid petrolatum as an external antiseptic and anti-irritant (Phenols and their derivatives)
p-Chlorophenol
Phenol coefficient of p-chlorophenol
4
A nonirritating antiseptic agent; marketed in a 2% conc. as a shampoo; used topically for the treatment of Tinea (ringworm) infections such as athlete’s foot (Tinea pedis) and jock itch (Tinea cruris) (Phenols and their derivatives)
p-Chloro-m-xylenol (PC-MX; Metasep)
A biphenol that generally possesses greater potency than a monophenol; increased degree of chlorination increases its antiseptic potency further; banned by the FDA as an OTC (Phenols and their derivatives)
Hexachlorophene
A mixture of isomeric methylphenols; has an unpleasant odor (Phenols and their derivatives)
Cresol
Phenol coefficient of cresol
2.5
A component of Strepsils that is an example of cresol derivative
Amylmetacresol
Is only slightly soluble in water; at the low concentration that can be achieved in aqueous media, the compound is only useful as a preservative (Phenols and their derivatives)
Chlorocresol (4-chloro-3-methylphenol)
Is extracted from the oil of thyme (Thymus vulgaris); has mild fungicidal properties and is used in alcohol solutions and dusting powders to treat Tinea (ringworm) infections (Phenols and their derivatives)
Thymol
Is obtained primarily from clove oil; has both anesthetic and antiseptic activity and can be directly applied on a piece of cotton to relieve toothaches; also used in mouthwashes (Phenols and their derivatives)
Eugenol
Phenol coefficient of eugenol
4.4
A weak antiseptic; a keratolytic agent; used in 1-3% concentrations in solutions, ointments, and pastes, and in 10-20% concentrations for the treatment of skin conditions (Phenols and their derivatives)
Resorcinol (m-Dihydroxybenzene; Resorcin)
Phenol coefficient of resorcinol
0.4
An effective antiseptic (both bactericidal and fungicidal); it possesses surfactant properties; has local anesthetic activity (Phenols and their derivatives)
Hexylresorcinol (4-Hexylresorcinol)
Phenol coefficient of hexylresorcinol
98
The germicidal activity of __________ depend on their ability to liberate oxygen in the tissues
Oxidizing agents
Is a stable complex of urea and hydrogen peroxide; used as an antiseptic and disinfectant; effective in the treatment of oral ulcerations and in dental care (Oxidizing agents)
Carbamide peroxide topical solution
In its pure powder form, it is explosive; in 5% & 10% concentrations, it is used as a keratolytic and keratogenic; it is used in the treatment of acne (Oxidizing agents)
Hydrous benzoyl peroxide
Used in iodine tincture, strong iodine solution, and iodine solution; one of the most effective and useful of the germicides
Elemental iodine (I2)
Probably acts to inactivate proteins by iodination of aromatic residues and oxidation; used as a bactericidal and fungicidal (Halogen containing agents)
Iodophors
Used in presurgical disinfection of the incision site; used to treat infected wounds and damage to the skin; effective for both bacterial and fungal infections (Halogen containing agents - iodophors)
Povidone-iodine (Betadine; Isodine; Polymer polyvinylpyrrolidone [PVP] - iodine)
2% iodine in 50% alcohol with sodium iodide (Examples of iodine preparations)
Iodine tincture
5% iodine in water with potassium iodide (Examples of iodine preparations)
Strong iodine solution (Lugol’s solution)
2% iodine in water with sodium iodide (Examples of iodine preparations)
Iodine solution
Optimal antiseptic effect of chlorine-containing compounds is at around pH __________
7
HClO (Organic or inorganic chlorine-containing compound)
Inorganic
NaOCl (Organic or inorganic chlorine-containing compound)
Inorganic
Ca(OCl)2 (Organic or inorganic chlorine-containing compound)
Inorganic
N-chloro compounds (Organic or inorganic chlorine-containing compound)
Organic
A photosensitive compound; is used to disinfect drinking water (Halogen containing agents - chlorine containing compounds)
Halazone (p-Dichlorosulfamoylbenzoic acid)
Unstable to light or heat; used in very dilute solutions to disinfect wounds, as packing for dental caries, and for lavage and irrigation (Halogen containing agents - chlorine containing compounds)
Chloroazodin (N,N-Dichlorodicarbonamidine; Azochloramid)
Chloroazodin explodes above __________°C
155°C
The antiseptic action of __________ is long lasting because of its extremely slow reaction with water (Halogen containing agents - chlorine containing compounds)
Chloroazodin
Is the complex of the sodium salt of dodecylbenzenesulfonic acid and hypochlorous acid; has rapid-cidal action against most microorganisms (Halogen containing agents - chlorine containing compounds)
Oxychlorosene sodium (Oxychlorosene; Clorpactin)
Compounds that are ionized in water and exhibit surface-active properties (Cationic surfactants)
Quaternary ammonium compounds
2 structural moieties of quaternary ammonium compounds
Cationic head group (hydrophilic); Long hydrocarbon tail (lipophilic)
Benzalkonium chloride, methylbenzethonium chloride, benzethonium chloride, cetylpyridinium chloride, and chlorhexidine gluconate are all examples of __________
Quaternary ammonium compounds (Cationic surfactants)
Cationic dyes are active against __________ bacteria and many fungi
Gram-positive
__________ bacteria are generally resistant against cationic dyes
Gram-negative
Used as vaginal suppository for treatment of yeast infection and anthelmintic for strongyloides and oxyuriasis (Dyes)
Gentian violet (Crystal violet; Methyl violet)
Used as an ingredient of carbolfuchsin (Castellani’s paint); treatment of fungal infection, ringworm, and athlete’s foot (Dyes)
Basic Fuchsin
Used as treatment for methemoglobinemia (low conc.) and is a cause of methemoglobinemia (high conc.); used as an antidote for cyanide poisoning (Dyes)
Methylene blue
Used for syphilis (Mercurials - inorganic mercury compounds)
Elemental mercury
Used as an antiseptic (Mercurials - inorganic mercury compounds)
Mercuric chloride, Mercurous chloride (Calomel)
Used for skin infections such as impetigo, psoriasis, and ringworm (Mercurials - inorganic mercury compounds)
Ammoniated mercury [Hg(NH2)Cl]
Used for eye infection (Mercurials - inorganic mercury compounds)
Mercuric oxide
Its use is not recommended (Types of mercurials)
Inorganic mercury compounds
2 types of mercurials (IO)
Inorganic mercury compounds, Organic mercury compounds
Usually employed as antiseptics, preservatives, or diuretics (Types of mercurials)
Organic mercury compounds
Compounds with at least one carbon-mercury bond _________ ionize readily
Does not
Compounds with mercury bonded to heteroatoms (e.g., oxygen, nitrogen, sulfur) ionize __________ or __________ (PC)
Partially, Completely
Organic mercury compounds react with sulfhydryl (-SH) groups in enzymes and other proteins to form covalent compounds of the type __________
R-S-Hg-R
Are used to prevent microbial contamination and maintain sterility
Preservatives
Have antifungal properties; activity generally increases with molecular weight (Preservatives)
p-Hydroxybenzoic acid derivatives
__________ is most effective against molds (Preservatives - p-hydroxybenzoic acid derivatives)
Methyl ester
__________ is most effective against yeasts (Preservatives - p-hydroxybenzoic acid derivatives)
Propyl ester
The more lipid-soluble __________ is the preferred preservative for drugs in oil or lipophilic base (Preservatives - p-hydroxybenzoic acid derivatives)
Propyl ester
4 examples of p-Hydroxybenzoic acid derivatives (MEPB)
Methylparaben, Ethylparaben, Propylparaben, Butylparaben
A p-Hydroxybenzoic acid derivative that is not used in products anymore
Butylparaben