Midaz

Question 1

Indicators for use

Answer 1

Prolonged seizures 
Agitated delirium and droperidol is unavailable or ineffective 
Pain with muscle spasm 
Sedation for joint relocation 
Sedation post intubation 
Severe anxiety with COPD

Question 2

Contraindications

Answer 2

Severe allergies

Question 3

Cautions for use

Answer 3

Administration of opiates, ketamine or other sedatives ( will prolong effect )
Intoxication
Elderly or frail

Question 4

MOA ( mechanism of action )

Answer 4

Midazolam is a benzodiazepine

Midazolam enhances the activity of gamma-aminobutyric acid (GABA) at GABA receptors within the central nervous system, resulting in anticonvulsant activity, sedation, amnesia, anxiolysis and muscle relaxation.

Question 5

Dose and route

Answer 5

5mg

IM: Draw up the dose from a 15 mg/3 ml ampoule. Do not dilute.
The preferred site is the lateral thigh as this has the best absorption. If this site is not suitable use the lateral upper arm.

IV: Dilute 2 ml from a 15 mg/3 ml ampoule to a total of 10 ml using 0.9% sodium chloride. This solution contains 1 mg/ml.
Administer IV as a bolus.

Question 6

Side affects

Answer 6

Sedation
Respiratory depression
Hypotension
Amnesia

Question 7

Drug life span

Answer 7

Onset:
IM: 3-5minutes
IV: 1-2 minutes

Duration: 30-60 minutes