mid term - questions Flashcards
write the contraindication of Progesterone?
- Breast cancer
- Pregnancy
- Uterine bleeding
- Liver diseases
Adverse effects of progestins?
- acne
- weight gain
- masculinization
- Lipid profile worsens (↓HDL, ↑LDL)
Clinical uses of progestins?
- Contraception
- Hormone replacement therapy
- Treatment of infertility
- Reduce the risk of recurrent spontaneous preterm birth (off-label)
Contraindications of estrogens?
- Estrogen-dependent neoplasms
- Breast cancer
- Liver disease
- Heavy smokers
Therapeutic uses of estrogens?
- Contraception
- Hormone replacement therapy
- Primary hypogonadism
- Hyperandrogenism
effects of estrogens?
- Growth and sexual maturation of female
- Decrease bone resorption
- Enhance coagulability of blood
- Improved lipid profiles
- Edema
why Oxytocin is not administered orally?
Ph sensitive and polypeptide so it will degrade in stomach
side effects of oxytocin
- Tachysystole
- tachycardia
- Hyponatremia
- Hypotension
- autism
Most effective tocolytic drugs?
*COX inhibitors
*calcium channel blockers
*beta-agonists
Less effective tocolytic drugs?
*Oxytocin receptor antagonists
*Magnesium sulfate
*Nitric oxide donors
Why we add Prostaglandin E1 (misoprostol); Prostaglandin E2(dinoprostone) to oxytocin?
cervical ripening and an increase in myometrial contractility
symptoms of menopause?
- Vasomotor symptoms
- Sleep disturbances
- Psychological disturbances
- Lipid changes
- Accelerated bone loss
Low-dose vaginal estrogen (cream, ring) for?
genitourinary syndrome of menopause
estrogen plus progestin replacement therapy?
- Breast cancer
- increased CHD, strokes, thrombosis
- reduced risk of colon cancer
- decrease in fracture risk
estrogen preparations?
Oral
Transdermal
Topical
Vaginal
progestin preparations?
- Medroxyprogesterone acetate
the most commonly prescribed progestin historically - Oral micronized progesterone
does not appear to increase the risk of either breast cancer or CHD - Levonorgestrel-releasing intrauterine device
oral combination
estradiol + norethindrone acetate
CEE + medroxyprogesterone
ethinyl estradiol + norethindrone acetate
Transdermal combination ?
17-beta estradiol + norethindrone acetate
Bazedoxifene (SERM)
agonist on bone,
antagonist on endometrium
Side Effect/ venous thromboembolic
give me 3 (SERM) drugs ?
Raloxifene
Bazedoxifene
Tomaxifene
Side effects of Raloxifene?
thrombotic disease
HRT: regimens?
- Unopposed estrogen
not recommended for healthy women - Cyclic combined regimens
daily estrogen with progestin on days 1 to 14 of each calendar month - Continuous combined regimens
both hormones are given every day
ADV of cyclic and continuous regimens?
Decrease risk of endometrial carcinoma
Dis Adv of continuous?
irregular bleeding & amenorrhea
HRT: contraindications?
- Breast cancer
- Endometrial cancer
- CHD
- Vaginal bleeding
alternative to relief of vasomotor symptoms?
Clonidine
what is the ttt of Hyperprolactinemic anovulation?
dopamine agonists
what is the ttt of Polycystic ovary syndrome (PCOS)?
Letrozole therapy & Clomiphene citrate
off-label use of Letrozole therapy
ovulation induction
Therapy for infertility?
1- Clomiphene citrate
2- Letrozole
3- Dopamine agonists
4- Pulsatile GnRH Therapy
5- Gonadotropin Therapy
6- Metformin
what is the MOA of Clomiphene citrate?
bind to estrogen receptors in the hypothalamus as an antagonist so it blocks the negative feedback as a result GnRH increases
Which of the following SERM is used for ttt of infertility?
Clomiphene citrate
SERM but they aren’t used for infertility?
Tamoxifen and raloxifene
Adverse effects of Clomiphene citrate?
-ovarian enlargement
-multiple gestation
-hot flash
This drug is an aromatase inhibitor
Letrozole
For oligo-ovulatory women with polycystic ovary syndrome (PCOS)
* is not US FDA approved for Letrozole
give her clomiphene citrate
why are multiple pregnany caused by clomiphene citrate?
bind to estrogen receptors in the hypothalamus as an antagonist so it blocks the negative feedback as a result GnRH increases
give me the Dopamine agonists?
Bromocriptine
Cabergoline
Ovarian hyperstimulation syndrome (OHSS) is adverse effect of which drug?
Gonadotropin Therapy
- correction of hyperinsulinemia with metformin
- increase menstrual cyclicity and improve spontaneous ovulation
Metformin
define Hormonal contraception
- Uses drugs that affect the function of estrogens and progestins to essentially eliminate the possibility of pregnancy
Two types of oral preparations?
- Combination oral contraceptives (COCs): estrogen plus progestin
- Progestin only pills
the most commonly used estrogen
Ethinyl estradiol
COCs MOA
- inhibition of LH , so no ovulation
- inhibition of FSH , so suppression of ovarian folliculogenesis
COCs: mild adverse effects
Nausea, edema, headache, skin pigmentation
COCs: moderate adverse effects
- Weight gain
- Acne
- Hirsutism
- Amenorrhea
COCs: severe adverse effects
- Thromboembolism
*cardiovascular disorders
*MI - Cerebrovascular disease
COCs: contraindications
- CVD
- HTN
- H.F
- DIBETES
what is the drug that accelerates COCs metaboLISM?
Phenytoin
Rifampin
what is the MOA of progesterone that is taken orally?
- thinning of the endometrium
- changes the composition of cervical mucous “less volume, and more thick”
- suppression of ovulation
Examples of Progestin-only pills (oral)
norethindrone, desogestrel
side effect of POP
Unplanned bleeding and menstrual irregularities
List Short-acting contraceptives
transdermal patch
vaginal ring
depot injection
List Long-acting contraceptives:
subcutaneous implant
intrauterine devices (IUDs)
non hormonal IUDs
Copper-releasing IUDs
what is the drug used as Postcoital contraceptives
levonorgestrel
gold standard to diagnose osteoporosis
dual-energy x-ray absorptiometry (DXA)
(osteopenia) is defined as
T-score between -1.0 to-2.5.