Hormones and their analogue drugs Flashcards

1
Q

somatorelin

A

sermorelin

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2
Q

somatotrophin

A

somatrophin

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3
Q

somatostatin

A

octreotide & lanreotide

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4
Q

TRH

A

protirelin

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5
Q

IGF-1

A

mecasermin

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6
Q

Dopamine agonist

A

cabergoline & bromocriptine & quinagolide & octreotide & Pegvisomant

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7
Q

GH antagonist

A

Pegvisomant

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8
Q

oxytocin antagonist

A

Atosiban

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9
Q

vasopressin analogs

A

1-vasopressin 2-Desmopressin 3-Terlipressina 4-Felypressio

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10
Q

ADH antagonist

A

demeclocycline and tolvaptan

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11
Q

what are the drugs that inhibit the release of GH?

A

Octreotide & Lanreotide & Somatostatin

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12
Q

what is the name of GHRF analogs?

A

Sermorelin

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13
Q

GHRIF inhibits the release of?

A

growth hormone and thyroid-stimulating hormone
insulin and glucagon
Decreases the release of gastric acids and GI hormones

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14
Q

released in pulsatile fashion

A

GH & GnRH

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15
Q

what is the use of synthetic CRF?

A

To diagnose ACTH

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16
Q

what is gonadorelin and what is the use of it?

A

it is analog of GnRH
use to TTT of infertility by release of FSH & LH

17
Q

what are the analogs of dopamine?

A

bromocriptine & cabergoline

18
Q

what factor stimulates GHRF?

A

ghrelin from stomach and pancreas

19
Q

what factor inhibit GHRF?

A

IGF-1

20
Q

what is the TTT of Turner syndrome?

A

somatropin

21
Q

Somatropin is prepared by

A

Recombinant DNA

22
Q

TTT of pituitary dwarfism?

A

somatropin & mecasermin

23
Q

TTT of acromegaly and gigantism?

A

Dopamine agonist 1-bromocriptine 2-octreotide 3-Pegrisomant

24
Q

TSH inhibited in 2 ways?

A

1-negative feedback mechanism 2-somatostatin

25
Q

what hormones stimulate prolactin secretion?

A

TRH, oxytocin & estrogen

26
Q

T or F antipsychotic drugs increase prolactin

A

T

27
Q

what type of receptor for Prolactin?

A

cytokine

28
Q

why ovulation doesn’t occur during breastfeeding?

A

because Prolactin inhibit gonadotrophin release

29
Q

What are the 2 uses of Bromocriptine and Dopamine agonist

A

1- (hyperprolactinemia) galactorrhoea 2- (Prolactinomas) Pituitarytumours

30
Q

where does vasopressin work on?

A

collecting tubule & distal Part of nephron

31
Q

what are the 2 stimulants of vasopressin release?

A

increase osmolarity and decrease circulating blood

32
Q

what is the function of ADH?

A

increase water reabsorption
increases Na + absorption
contraction of smooth muscle
stimulates blood platelet aggregation and coagulation
have a role in emotional and social behaviour
ADH is a partial agonist of oxytocin receptors

33
Q

what is TTT of Diabetes insipidus

A

1 Vassoprin 2 Desmopressin 3 Terlipressin 4 Felypression

34
Q

what is the main side effect of ADH

A

angina

35
Q

what are the drug-increased vasopressin effects?

A

1 NSAID 2 carbamazepine

36
Q

what are the drug-decreased vasopressin effects?

A

1-Lithium 2-colchicine

37
Q

Patients with hyperprolactinemia we give them

A

Dopamine, bromocriptine, cabergoline

38
Q

what is the use of octeotide?

A

1- treat tumors
- Carcinoid tumours
* Glucagonomas
* Pituitary adenomas
* Tumours releasing vasoactive intestinal peptides
2- treat acromegaly

39
Q

ttt of thyroid tumor?

A

Lanreotide