Hormones and their analogue drugs

Question 1

somatorelin

Answer 1

sermorelin

Question 2

somatotrophin

Answer 2

somatrophin

Question 3

somatostatin

Answer 3

octreotide & lanreotide

Question 4

TRH

Answer 4

protirelin

Question 5

IGF-1

Answer 5

mecasermin

Question 6

Dopamine agonist

Answer 6

cabergoline & bromocriptine & quinagolide & octreotide & Pegvisomant

Question 7

GH antagonist

Answer 7

Pegvisomant

Question 8

oxytocin antagonist

Answer 8

Atosiban

Question 9

vasopressin analogs

Answer 9

1-vasopressin 2-Desmopressin 3-Terlipressina 4-Felypressio

Question 10

ADH antagonist

Answer 10

demeclocycline and tolvaptan

Question 11

what are the drugs that inhibit the release of GH?

Answer 11

Octreotide & Lanreotide & Somatostatin

Question 12

what is the name of GHRF analogs?

Answer 12

Sermorelin

Question 13

GHRIF inhibits the release of?

Answer 13

growth hormone and thyroid-stimulating hormone
insulin and glucagon
Decreases the release of gastric acids and GI hormones

Question 14

released in pulsatile fashion

Answer 14

GH & GnRH

Question 15

what is the use of synthetic CRF?

Answer 15

To diagnose ACTH

Question 16

what is gonadorelin and what is the use of it?

Answer 16

it is analog of GnRH
use to TTT of infertility by release of FSH & LH

Question 17

what are the analogs of dopamine?

Answer 17

bromocriptine & cabergoline

Question 18

what factor stimulates GHRF?

Answer 18

ghrelin from stomach and pancreas

Question 19

what factor inhibit GHRF?

Answer 19

IGF-1

Question 20

what is the TTT of Turner syndrome?

Answer 20

somatropin

Question 21

Somatropin is prepared by

Answer 21

Recombinant DNA

Question 22

TTT of pituitary dwarfism?

Answer 22

somatropin & mecasermin

Question 23

TTT of acromegaly and gigantism?

Answer 23

Dopamine agonist 1-bromocriptine 2-octreotide 3-Pegrisomant

Question 24

TSH inhibited in 2 ways?

Answer 24

1-negative feedback mechanism 2-somatostatin

Question 25

what hormones stimulate prolactin secretion?

Answer 25

TRH, oxytocin & estrogen

Question 26

T or F antipsychotic drugs increase prolactin

Answer 26

T

Question 27

what type of receptor for Prolactin?

Answer 27

cytokine

Question 28

why ovulation doesn’t occur during breastfeeding?

Answer 28

because Prolactin inhibit gonadotrophin release

Question 29

What are the 2 uses of Bromocriptine and Dopamine agonist

Answer 29

1- (hyperprolactinemia) galactorrhoea 2- (Prolactinomas) Pituitarytumours

Question 30

where does vasopressin work on?

Answer 30

collecting tubule & distal Part of nephron

Question 31

what are the 2 stimulants of vasopressin release?

Answer 31

increase osmolarity and decrease circulating blood

Question 32

what is the function of ADH?

Answer 32

increase water reabsorption
increases Na + absorption
contraction of smooth muscle
stimulates blood platelet aggregation and coagulation
have a role in emotional and social behaviour
ADH is a partial agonist of oxytocin receptors

Question 33

what is TTT of Diabetes insipidus

Answer 33

1 Vassoprin 2 Desmopressin 3 Terlipressin 4 Felypression

Question 34

what is the main side effect of ADH

Answer 34

angina

Question 35

what are the drug-increased vasopressin effects?

Answer 35

1 NSAID 2 carbamazepine

Question 36

what are the drug-decreased vasopressin effects?

Answer 36

1-Lithium 2-colchicine

Question 37

Patients with hyperprolactinemia we give them

Answer 37

Dopamine, bromocriptine, cabergoline

Question 38

what is the use of octeotide?

Answer 38

1- treat tumors
- Carcinoid tumours
* Glucagonomas
* Pituitary adenomas
* Tumours releasing vasoactive intestinal peptides
2- treat acromegaly

Question 39

ttt of thyroid tumor?

Answer 39

Lanreotide