Drugs used to treat cough Flashcards
drug cause cough?
Angiotensin-converting enzyme inhibitors
It opens disulfide bonds in mucoproteins present in sputum
Acetylcysteine
Side effects is gastric irritation, hypersensitivity
Bromhexine
this durg action is blocked by naloxone
Codeine
is believed to be less constipating
Ethylmorphine
Metabolites of Bromohexine
Ambroxol
Side effect is constipation and in children respiratory depression
Codeine
useful in spasmodic cough
Noscapine (Narcotine)
useful in chronic bronchitis, asthma
Mucolytics
has no analgesic or addicting property
Pholcodeine
Uses Cystic fibrosis
Acetylcysteine
It depolymerises mucopolysacchrides directly as well as liberating
lysosomal enzymes network of fibres in tenacious sputum is broken
Bromhexine
lack selectivity for cough center
Antihistamines
MOA of Dextro-methorphan
- A synthetic central NMDA
- (N-methyl D-aspartate) receptor antagonist; also antagonize opioid
receptors; - antitussive action
- analgesic.
- Non-addicting. The antitussive action of dextromethorphan has
been rated equivalent to codeine.
E.g of Antihistamines
Chlorpheniramine
diphenhydramine
promethazine