Microsporidia

Question 1

Some biological characteristics of microsporidia

Answer 1

Gram positive, intracellular, spore forming organism

Question 2

Special feature about the parasite?

Answer 2

Polar tubule

Question 3

Examples of eukaryotic organelles they lack

Answer 3

Mitochondria( mitosomes instead)
Peroxisomes
Golgi body

Question 4

How many layers does it have?

Answer 4

2
Endospore: made of chitin.electronlucent
Exospore: made of protein, electrondense

Question 5

Infective stage of organism

Answer 5

Spore

Question 6

Examples of acid fast organisms

Answer 6

Isospora belli(oocyst) cryptosporidium pervum( oocyst) cyclospora cateyanesis (oocyst)
Microsporidia (spores)

Question 7

Some species of microsporidia include

Answer 7

Encephalitozoon cuniculi, encephalitozoon intestinal is
Encephalitozoon hellem
Enterocytozoon bieneusi

Question 8

Most susceptible to microsporidia specifically E bieneusi

Answer 8

Immunocompromised individuals
Including HIV infected people less than 100 CD4+

Question 9

What species are associated with a less than 50 CD4+ count

Answer 9

Enterocytozoon bieneusi and encephalitozoon intestinal

Question 10

Source of infection

Answer 10

Domestic and wild animals.. zoonotic

Question 11

Stages in microsporidia life cycle

Answer 11

Merozoite stage( proliferating stage)
Spore stage( mature)

Question 12

What is the covering around a meront?

Answer 12

Parasitophorous vesicle

Question 13

Life cycle?

Answer 13

Spore to sporoplasm to meront to sporont to sporoblast to mature spore

Question 14

Clinical features

Answer 14

Microsporidia: diarrhea and wasting, encephalitis, keratitis, sinusitis

Question 15

Treatment

Answer 15

Metronidazole, albendazole, benzimidazole, fumagillin, neomycin