Leishmania Donovani

Question 1

Characteristic if leishmania

Answer 1

Obligated intracellular parasites

Question 2

Disease caused by L donovani

Answer 2

Visceral leishmaniasis also called kala azar
Also post kala azar dermal leishmaniasis PKDL

Question 3

The amastigote forms is also called

Answer 3

LD body

Question 4

Amastigote characteristics in Giesma or wright’s stain

Answer 4

Pale blue cytoplasm. Red nucleus next to red or purple kinetoplast

Question 5

Definitive and intermediate host?

Answer 5

Mammal: definitive
Vector: intermediate

Question 6

Pathogenesis of kala azar

Answer 6

Affect liver, spleen, reticuloendothelial system, bone marrow, RBC destruction, affects Kupffer cells but not hepatocytes

Question 7

Clinical features of kala azar

Answer 7

Severe Anemia
Hepatomegaly
Splenomegaly
Leucopenia
Thrombocytopenia
Cachexia ( weakness, wasting)
Epistaxis

Question 8

PKDL

Answer 8

Non ulcerative lesions on the skin

Question 9

Kala azar causes production of what antibodies

Answer 9

IgG igM

Question 10

Lymph node aspirate is useful in

Answer 10

African kala azaR, not indian

Question 11

Treatment of kala azar

Answer 11

Pentavalent antimonial compounds (sodium stibogluconate)
Amphotericin B deoxycholate in antimonial resistance
Amphotericin B