Microscopic Polyangitis Flashcards
1
Q
What is Microscopic Polyangitis?
A
An ill-defined autoimmune disease characterized by a systemic, pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of necrotizing granulomatous inflammation.
2
Q
What is the pathophysiology of Microscopic Polyangitis?
A
- Necrotising vasculitis, with few or no immune deposits, predominantly affecting small vessels.
- Necrotising glomerulonephritis is very common
- Pulmonary capillaritis often occurs
- Granulomatous inflammation is absent
3
Q
What are the main features of microscopic polyangitis?
A
- Fever
- Loss of appetite
- Weight loss
- Fatigue
- Kidney failure - haematuria, proteinura, rapidly progressive glomerulonephritis
- Pulmonary haemorrhage
4
Q
What tests would you do if you suspected vasculitis?
A
- Bloods - CRP, ESR, FBC, U+E’s, LFTs, ANCA
- Urinalysis
- CXR
- Renal Biopsy
5
Q
What blood test is most commonly associated with Microscopic polyangitis?
A
p-ANCA for MPO
