Eosinophilic granulomatosis with polyangitis (EGPA)

Question 1

What is Eosinophilic Granulomatosis with polyangitis?

Answer 1

Churg-Strauss

Autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy).

Question 2

What is the pathophysiology of Eosinophilic Granulomatosis with polyangitis?

Answer 2

• Eosinophil rich and necrotising granulomatous inflammation often involving the respiratory tract
• Necrotising vasculitis predominantly affecting small to medium vessels
• Associated with asthma and eosinophilia
• ANCA is more frequent when glomerulonephritis is present

Question 3

What is the triad of features seen in Churg-Strauss?

Answer 3

• Vasculitis
• Asthma
• Eosinophilia

(+/-vasospasm, MI, DVT)

Question 4

What antibody is EGPA most commonly associated with?

Answer 4

pANCA with MPO positive