Microbiology-Pharmacology

Question 0

Beta lactams

Answer 0

Inhibit transpeptidase (cell wall synthesis). Penicillins, cephalosporins, aztreonam, imipenem

Question 1

Bactericidal

Answer 1

Beta lactams, fluoroquinolones, aminoglycosides, metronidazole

Question 2

Act on cell wall

Answer 2

Beta lactams, vanco, bacitracin, polymyxins

Question 3

Act on 30S

Answer 3

Aminoglycosides, tetracyclines

Question 4

Act on 50S

Answer 4

Linezolid, clindamycin, chloramphenicol, macrolides

Question 5

Penicillin

Answer 5

Beta lactam. Syphilis. SE: hypersensitivity, rash, hemolytic anemia.

Question 6

Aminopenicillins

Answer 6

Ampicillin, amoxicillin.
Enterococcus, listeria. 2nd line for Lyme.
SE: hypersensitivity, rash, pseudomembranous colitis

Question 7

Piperacillin

Answer 7

Pseudomonas

Question 8

Cephalosporins

Answer 8

Beta lactam.
1st gen-cefazolin, cephalexin
2nd gen-cefotetan, cefuroxime
3rd gen- cefoperazone, ceftazidime, ceftriaxone

SE: 5-10% pts with penicillin allergy also react to cephs. Ohm dome have disulfiram like reaction.

Question 9

Aztreonam

Answer 9

Beta lactam. G- rods. Safe in pregnancy. Usually nontoxic.

Question 10

Carbapenems

Answer 10

Imipenem/cilastatin, meropenem. Resistant G- infections. Cilastatin prevents renal metab of imipenem.
SE: hypersensitivity and rash, GI distress, drug fever, seizures if renal dysfunction (less with meropenem)