Microbiology Chapter 15

Question 1

Any molecule that stimulates an immune response

Answer 1

Antigen (Ag)

Question 2

B Cell receptor is what kind of a molecule?

Answer 2

Immunoglobulin (Ig)

Question 3

B cells receptors are secreted as what?

Answer 3

Antibodies (Ab = Ig)

Question 4

What is never secreted?

Answer 4

T-Cell receptor (TCR)

Question 5

List the Antigen Presenting Cells (APC)

Answer 5

Macrophages, B-Cells, and Dendritic Cells (Macrophage-like cell in tissue)

Question 6

What are the functions of APC?

Answer 6

Process and present antigen in association with MHC II (cell surface protein on host cells). T-Cell receptor recognize antigen/MHC complex.

Question 7

Thought to secrete interleukin; a cytokine which suppresses helper T-Cells

Answer 7

Regulatory B-Cell

Question 8

Secreted protein that regulates other cells

Answer 8

Cytokine

Question 9

Immunoglobulin classes

Answer 9

IgG, IgA, IgM, IgD, IgE

Question 10

Based on the Fc (constant region) fragment

Answer 10

Isotopes

Question 11

Most prevalent in tissue fluid and blood. Only one to cross Placenta.

Answer 11

IgG

Question 12

Monomer or dimer (secretory IgA). Dimer - two Ig held together by a J chain. Secretory IgA is there for local immunity (salivary glands, intestine, nasal membrane, breast, lung, genitourinary tract. Provides protection for newborns.

Answer 12

IgA

Question 13

Pentomer (five monomers). First to be synthesized during primary immune response. Associated with complement activation. Circulates in the blood

Answer 13

IgM

Question 14

Monomer. Small amounts in the serum (rarely secreted). Receptor for antigen on B-cells is its only function.

Answer 14

IgD

Question 15

Activates during allergies and parasite infections.Constant region binds to mast cells and basophils which release chemical mediators that aid inflammation.

Answer 15

IgE

Question 16

Direct Involvement of T-Cells. Produce and react to cytokines. Activated simultaneously with B cell activation. Subset of T cells have unique CD receptors (CD4, CD8)

Answer 16

Cell-Mediated Immunity

Question 17

Types of T-cells

Answer 17

Helper T-cells (TH) CD4+

Cytotoxic T cells (TC) CD8+

Question 18

What helps T-cell bind to Ag on MHCII

Answer 18

CD4

Question 19

Binds and lyses infected cells and cancer cells

Answer 19

Cytotoxic Cells

Question 20

T-helped cell binds to Ag plus MHC II on antigen presenting cell.

Answer 20

TH cell Activation

Question 21

T-cytotoxic cells binds to Ag plus MHC I on target cells (cells to be killed)

Answer 21

TC Activation