Microbiology, Antibiotics, Inhibition of nucleic acid synthesis

Question 1

Levoflaxin

Answer 1

• inhibitor of nucleic acid synthesis
• newer quinolones
• affects Pneumococci, Chlamydia psittacci, Coxiella burnetti, Mycoplasma pneumonia (mostly pneumonia)

Question 2

Nalidixic acid

Answer 2

• inhibitor of nucleic acid synthesis
• quinolones
• G- aerobes (coliforms)

Question 3

Nitrofurantoin

Answer 3

• inhibits nucleic acid synthesis
• lower UTI
• G- (mostly), except Proteus & Pseudomonas species & some gram positive

Question 4

Trimethoprim

Answer 4

• inhibitor of nucleic acid synthesis
• trimethoprim & sulphamethoxazole
• treats urinary infections (inhibits purine synthesis)

Question 5

Ciproflaxacin

Answer 5

• inhibitor of nucleic acid synthesis
• fluroquinolones
• nearly all G- including pseudomonas
• no usage on children (interference with cartilage growth)

Question 6

Quinolone

Answer 6

• inhibitor of nucleic acid synthesis
• quinolones
• affects G- and Staphylococcus and Streptococcus (G+)
• the only oral solution against pseudomonas