Microbiology 3 - Antimicrobial Agents 2 Flashcards
What mnemonic can be used to help decide which antibiotic to use?
CHAOS Choice depends on the: Host charcteristics Antimicrobial susceptibilities of the Organism itself, as well as the Site of infection
What is the Minimum Inhibitory Concentration and Breakpoint of an antibiotic useful for?
Working out sensitivity
MIC > breakpoint = resistant
MIC < breakpoint = sensitive
What antibiotic should be given for gram pos cocci in clusters?
Flucloxacillin
What antibiotic should be given empirically for gram neg cocci?
Ceftriaxone (could be meningococcus)
What is the “eagle effect”?
Increasing the penicillin dose –> decreasing antibacterial activitity after a point
How does the choice of antibiotic to treat UTI differ between community and hospital?
Community: nitrofurantoin/ trimethoprim
Hospital: cephalexin/ augmentin