Microbio revision Flashcards
Examples of cfluoroquinolones
Ciprofloxacin, Movifloxacin,
What are the features of penicillins?
They inhibit cell wall synthesis
Some are not absorbed orally
Allergy to 1 = allergy to all
Bactericidal
Which drug can you administer even if you have penicillin allergy?
aztreonam (monobactam)
Which penicillins have very less oral bioavailability?
Piperocillin-tazobactam
Which antibiotic is most likely to cause photosensitivity?
Doxycycline
Which of these drugs lower to CGHS threshold/ can worsen epileptic control?
All quinolones -> levofloxacin
Which of the following would prvide inadequate pathogen cover for respiratory streptococcus penumoniae?
Doxycycline Clarithromycin Co-amoxiclav Ciprofloxacin Amoxicillin
Ciprofloxacin (only Levofloxacin is useful)
What is the main purpose of adding clarithromycin to pneumonia treatment?
to cover atypical organisms
What is the best antibiotic for strep-pneumoniae treatment?
Amoxicillin
Which of the following is not absorbed systemically when given by mouth?
Clindamycin Clarithromycin Vancomycin Ciprofloxacin Ciprofloxacin Aztreonam
Vancomycin
How is aztreonam administered?
IV
Regarding C.Diff which of the following is false?
It is anaerobic.
It forms spores.
It can be carried asymptomatically.
It causes mainly mil, self-limiting infection.
It icauses mainly mild, self-limiting infections
Diagnostic tests for C.Diff
PCR, C-Diff toxin
What is the 1st line monotherapy for mild cases of pneumonia?
amoxicillin
Which is a major risk factor for pneumonia?
Smoking
Is a positive sputum culture compulsory for pneumonia diagnosis?
No, in context of a good clinical history
Why is amoxicillin not the empirical choice for the treatment for the treatment of Ecoli?
upto 40% of Ecoli is resistant to Amoxicillin
Amoxicillin and gentamicin in UTI treatment for what?
Amox - enterococcus
gent - g. negative
Which of the following is the most FALSE for quinolone?
Associated with AAA rupture
Associated with psychiatric side effects
May cause diffuse tendonitis
Stop immediately and seek advice if diarrhoea occurs
oral bioavailability is almost as good as IV
oral bioavailability as good as IV – as it is even better
Why is quinolone used orally for pseudomonas in penumonia?
As it’s oral bioavailability is good
Clindamycin is not active against this organism:
Proteus mirabella
What does clindamycin cover?
Strep pyogenes
Staph aureus
Anaerobes (metronidazoleand clinda)
Which is the only one used as an IV preparation?
Aztreonam (only IV)
Gentamicin (IV but it has ear drops as well –> hence if btw the two aztreonam)
Which iof these is a gram positive bacillus?
Salmonella enteridis Campylobacter jejuni Listeria monocytogenes Listeria monocytogenes Shigella flexnerii Cryptosporidium spp.
Listeria monocytogenes
What type of bacteria is cyptosporidium?
Not a bacteria
What other disease can listeria cause?
Meningitis
Which drug has a high liver toxicity?
Co-amoxiclav
Which of the following would you expect to be raised in sepsis secondary ot bacterial infection?
Interleukin 6
CRP
WBCC
Platelet count
Interleukin-6, CRP< WBCC
Not raised Platelet count
Which of the following is not an AIDS defining condition?
Recurrent pneumonia
Oropharyngeal candida
Salmonella bacteraemia
Recurrent endpcarditis
Recurrent Endocarditis
Which of the following is not an AIDS defining condition?
Recurrent pneumonia
Oropharyngeal candida
Salmonella bacteraemia
Recurrent endocarditis
Recurrent Endocarditis
Salmonella in strange places like blood can occur in which rare conditions?
Sickle cell disease
AIDS
Which of the drugs works for an ESBL producing Klebsiella?
Ceftriaxone
Aztreonam
Vancomycin
Meropenem
Meropenem
Vancomycin - neveer active against gram negatives
Which of the following is not one of the typoical endocarditis organisms in the major DUKES criteria?
Kingella kingsae
Bartonella henselae
Enterobacter clocaea
Enterococus faecalis
Enterobacter cloacae - gram negative
Kingella kingsae - HACEK
Bartonella, coxsiella - seronegative ones
Enterococcus faecalis - it is there
Which of the statement is flase?
Rifampicin can reduce the effect of warfarin
Rifampicin can increase the effect of clopidogrel
Iron can reduce the effect of doxycycline
Metronidazole can reduce the lithium concentration
Metronidazole can reduce the lithium concentrations
Which if the following is true?
Tetracyclines should be avoided in children < 12y
Rifampicin can cause orange eyes
