Definitions

Question 1

Colonisation

Answer 1

presence of a microbe in the human body without an inflammatory response

Question 2

Infection

Answer 2

Redness and soreness and inflammation due to a microbe

Question 3

Bacteraemia

Answer 3

Presence of a viable bacteria in the blood

Question 4

Sepsis

Answer 4

life-threatening organ dysfunction caused by a dysregulated host response to bacteria

Question 5

Septic shock

Answer 5

a subset of sepsis with circulatory and cellular/ metabolic dysfunction associated with a higher risk of mortality

Question 6

SIRS

Answer 6

Sources of infection -> bacteria enters the blood ->

Question 7

Progression of Sepsis

Answer 7

colonisation -> infection -> SIRS -> Sepsis -> severe sepsis -> septic shock

Question 8

Sepsis 6

Answer 8

O2
GFLuid rescusitation
blood culture
Stat IV Antibiotics
lactate
monitor urine output

Question 9

Sepsis 6

Answer 9

O2
Fluid rescusitation
blood culture
Stat IV Antibiotics
lactate
monitor urine output

Question 10

Sequrential Organ Function Assessment Score (SOFA)

Answer 10

Used in intensive care

Very complicated

1.respiration
2.Coagulation platerlets
3.liver
hypercoaguability

Question 11

Use of qSOFA - likelikhood of mortality

Answer 11

RR >22
sBP <100 mmHg
Altered GCS

Screening for outcome rather than diagnosis

0 - mortality <1%
1- Mortality 2-3%
>2 - mortality >/10%

Question 12

How can you differentiate sepsis from septic shock?

Answer 12

If an attempt has been made at fluid rescuscitation

Question 13

30 day Mortality rate with NEWS 0-4

Answer 13

5.5%

Question 14

How do we diagnose SEPSIS?

Answer 14

NEWS Score in the context of infection

> 5 think SEPSIS