Microarrays

Question 1

Types of microarrays

Answer 1

Spotted dna microarrays
Oligonucloetide arrays
- gene chips (affymetrix)
- ink jet microarrays (agilent)

Question 2

PWS mutation

Answer 2

Deletion on long atm chr15

Question 3

What does wBS stand for, what is the causative mutation

Answer 3

Williams beuren syndrome
Deletion of 27 genes from ch7

Question 4

Causative mutation in Charcot Marie aTppth Disease Type 1

Answer 4

Duplication on chr17

Question 5

4 methods of detecting CNVs

Answer 5

Karyotyping
Fish
Microarrays (oligo and bac)
Microarrays -> array cgh

Question 6

What is array cgh the gold standard for

Answer 6

Intellectual disability/developmental delay

Autism spectrum disorder

Multiple congenital anomalies

Question 7

Gene expression array method

Answer 7

Question 8

Example of a gene expression array

Answer 8

MammaPrint dx 70-gene

Question 9

What does cgh stand for

Answer 9

Comparative genomic hybridisation

Question 10

Method of array cgh

Answer 10

Question 11

Method of array cgh

Answer 11