Microangiopathic haemolytic anaemia Flashcards
1
Q
Which feature of blood film is associated with microangiopathic haemolytic anaemias?
A
shistocytes
2
Q
What are the causes of microangiopathic haemolytic anaemias?
A
haemolytic uraemic syndrome TTP DIC malignancy vasculitis pre-eclampsia
3
Q
What is the pathophysiology of thrombotic microangiopathies?
A
endothelial damage, platelet activation followed by consumption leading to thrombosis
4
Q
Which enzyme deficiency is present in TTP?
A
ADAMTS13
5
Q
What are the causes of TTP?
A
idiopathic, pregnancy, malignancy, HIV associated
6
Q
What are typical blood results found in DIC?
A
PT and APTT prolonged
reduced platelets
raised D dimer -> one of the main causes of massively increased D dimer!!!
