Micro. ch.17 Flashcards
Adaptive Immune system
adapt to a specific microbial invader or a foreign substance.
Antigen
chemical substance that cause the body to produce specific antibody (Ab) then binds with Ab.
Antigens
Protein or large polysaccharides
Epitopes
Hapten
Antibodies
(Immunoglobulin)
protein produced by B cells in response to a specific antigen
5 classes of Antibodies
IgG IgM Serum IgA IgD IgE
IgG
Class of antibodies
Most prevalent in serum
provide naturally acquired passive immunity
neutralize bacterial toxins
IgG
Class of antibodies
participate in complete fixation
enhance phagocytosis
half live:23 days
IgM
Class of antibodies consist of 5 monomers (pentamer) held by a joining chain involved in -agglutination -complete fixation
IgM
Class of antibodies
Appears slowly but is the first antibody formed in an infection.
more effective then IgG
Half life: 5 days
large amounts: uniquely valuable in diagnosis in current disease
Serum IgA
Class of antibodies
Half life: 6 days
monomer antibodies
Secretory … antibodies are dimer protect mucosal from path. invasion
IgD
Class of antibodies Half life: 3 days Antibodies on T cells delete B cells that produce antibodies against it self .2% Abs
IgE
Class of antibodies
Antibodies bind to mast cells and basophils
involved in allergic reactions and parasites
half life: 2 days
Immunological Memory
Antibody titer
Primary response
Secondary response
primary response
Immunological Memory First contact with antigen characterized by: Appearance of IgM then IgG
Primary Response IgG
Immunological Memory
Is longer lasting then IgM
and forms second
its presence in serum may only indicate patient has been exposed to antigen in past
