micro - bacteria Flashcards
induces TNF and IL-1
lipiteichoic acid in cell wall, Lipid A
has cell wall
Gm +
has outer membrane
Gm -
mediates adherance to structures
glycocalyx
has lipoteichic acid
Gm +
has endotoxin/LPS
gm -
thick peptidoglycan
gm +
gm + coccus
staph, streo
gm - coccus
neiserra
gm + rod
clostridium cornyebacterium baccillus listeria mycobacteria (acid fast) gardinella (gm variable)
gm - rod
enterics, respiratory, zoonotic
branching filamentous
actinomyces
nocardia (weakly acid-fast)
pleomorphic
rickettsiae
chlamydiae
spiral
leptospira
borrelia
treponema
no cell wall
mycoplasma
wall contains sterols
mycoplasma
wall contains high lipid content
mycobacteria
bugs that don’t gram stain well
treponema rickettsia mycobacteria mycoplasma legionella chlamydia
stains for chlymidia, borrelia, rickettsia, trypansomes, plasmodium
giemsa
PAS stains for
tropheryma whipplei
zeihl-neesen stains
acid-fast bugs
india ink stains
cyrptococcus
silver stain stains
fungi, legonella, heliobacter
grows H flu
chocolate agar
growsNeiseria
thayer-martin/VPN
grows pertuussis
bordet-gengou
grows diptheria
tellurite
grows TB
lowenstein-jensen
grows M pneumonia
eaton’s agar
grows lactose fermenting enterics
pink colonies on macConkey’s
grown E coli
green metallic on EMB
grows fungi
Sanoraroud
obligate aerobes
nocardia, p aeuroginoa, TB, bacillus
aerobe found in burn wounds
P aerugnosa
oblugate anerobes
clostridium, bacteroides, actinomyces
obligate intracellular bugs
chlamydia, rickettsia
faculative intracellular bugs
salmonella neiserria brucella mycobacterium listeria francisella legionella yersina pestis
encapsulated bacteria
strep pnemonia hemophilus flu B neiseria meningitidis E coli salmonella klabsiella pneumoniae group B strep
catalase +
pseudomonas listeria aspergilllus candida staph A serratia
polysaccaride vax with no conjugated protein
pneumovax
conjugated vax
H flu B
meningococcal
urease +
cryptococcus H pylori proteus ureaplasma nocardia klebsiella staph epidermis S saprophyticus
binds Fc region of Ig, preents opsonization and phagocytosis
protein A (staph a)
cleaves IgA
IgA protease (s pnemonia, H flu, neisseria)
prevents phagocytosis - expressed by group A strep
M protein
diseases of exotoxins
tetanus, botulism, diptheria
diseases of endotoxins
meningococcemia, gram - sepsis
location of genes for exotoxins
plasmid/bacteriophage
location of genes for endotoxins
bacterial chromosome
more toxic: endo/exotoxin
exotoxin
more heat stable endo/exotoxin
endotoxin
causes fever and shock
endotoxin
contaiend in cell membrne of most gm -
endotoxin
MOA of diptheria toxin/Exotoxin A (pseudomonas aeruginosa)
initates Elongation factor (EF-2)
MOA of shiga (shigella) /shiga-like toxin (EHEC)
inactivates 60S ribosome by removng adenine from rRNA
MOA of heat-labile (ETEC) roxin
overactives adenalyte cyclase –> cAMP –> Cl-secretion in gut and water efflux
MOA of heat-stable (ETEC) toxin
overactivates cGMP –> lowers salt/water reabsorption in gut
MOA of edema factor (anthrax)
mimics the adenylate cyclase enzyme –> increasing cAMP
MOA of cholera toxin
permanatly increases cAMP –> increases Cl secretion in gut and water efflux
MOA of pertussis toxin
increases cAMP, impairs phagicytosis
MOA of tetanus/botulism toxin
Cleaves SNARE protein required for NT release
pharyngitis with psedomembranes and “bull neck lymphadenopathy”
diptheria
dysentrary and HUS
shigella
HUS w/o dystentary
EHEC
watery diareeha
ETEC
black eschar in skin,
anthrax (cutaneous)