Mice Flashcards
What family of mice is considered “house mice”?
Muridae family or Swiss albino mouse
Unlike other mammals, what remains active throughout their life?
Marrow of long bone
What is barbering?
Chewing off of hair of cagemates
What in males is 50% larger than females?
Spleen
What is the average life span of a mouse?
12-36 months
What is the recommended humidity?
45-55%
What is the recommended environmental temp?
24-25 C
Mice have __ pairs of mammary glands that extend to sides and back
5 pairs
What type of estrus do mice have?
Continuously polyestrus
What should be done to females to decrease likelihood of cannibalism?
Leave females undistrubed for 2 days after parturition
At what age do females mice develop nipples?
9 days
At what age do mice pup ears open?
Day 3
At what age do mice pups eyes open?
Day 12-14
What is the most common breeding system?
Polygamous (1 male with several females)
Until what age are females bred?
9 months
What is the term for when large groups of female mice aer housed together without the presence of a male, allowing females to go into anestrus and allows for timed mating
Whitten Effect
What is the term for if a pregnant mous is exposed to a new male or its odor within 4 days of breeding. The existing pregnancy will be aborted and the female will return to estrus
Bruce Effect
What are some commonly used outbred stocks of mice?
Swiss, swiss Webster, CD 1, CFI SKH1
What outbred stock is the hairless breed?
SKH1
Most cases of pneumonia are caused by what bacteria?
Mycoplasma pulmonis
What bacteria is responsible for Tyzzers disease?
Bacillus piliformis
Why is Tyzzers difficult to eradicate?
Resistant spores
Bacterial disease that may be fatal in athymic mice or immunocompromised mice
Pasteurellosis
Heliobacter bacteria that can cause IBD and hepatic tumors
Hepatitis
Treatment for hepatitis includes amoxicillen, metronidazole, and bismuth PO SID X 2 weeks and should never be given via what method?
Never put in water
What two bacterial diseases are zoonotic?
Lepto and streptobacillus moniliformis
What is the primary agent of viral respiratory disease?
Sendai virus
Viral disease uncommon in the US, mouse is the only known host, highly contagious, can be acute, chronic or latent
Mousepox or ectromelia
Zoonotic viral disease spread via aersols, bite wounds, transplacental, arthropod vectors. Infected in utero.
Lymphocytic choriomeningitis
Corona virus of mice. Enteric strains are most common, altho respiratory strains exist. Treatment not usually attempted
Mouse hepatitis virus
Clinical disease only seen in suckling mice, dread fecal oral route, transplacental. Potentially zoonotic. No treatment
Reovirus type 3
Acquired through close contact with birds or their feces
Histoplasma capsulatum
Rickettsial blood parasite
Eperythrozoon coccoides
Most common neoplasia in random bred mice
Pulmonary tumors
Trauma in mice housed together, lesions often become infected with what?
S. aureus
What are best used to monitor mice under anesthesia?
NM system and RR
What makes mice useful for teratology, genetics and gerontology?
High fecundity, short gestation, short life span
Susceptibilty to specific viruses and development of certain tumors makes mice useful in what studies?
Virology and oncology
Bacterial disease characterized by thickening of intestinal mucosa, mice are most affected species, symptoms include exposive diarrhea and prolapsed rectum.
Transmissible murine colonic hyperplasia
~citrobacter freundii
What two bacterial diseases are dermatitis?
S. aureus and Streptococcus species
How is Sendai virus spread?
Direct contact or aerosol contamination
Treatment for mousepox (ectromelia)?
None
What serves as the source of infection for mousepox?
Older animals that harbor infection in GI tract
Chronic rash and swelling/necrosis of limbs is indicative of what disease?
Mousepox
What is the main source of Mousepox (ectromelia)?
Mice/biologics imported
How is mouse hepatitis virus transmitted?
Direct contact, oral-nasal, fomites, transplacental
True or False
Systemic infections in mice are rare
True
What is the intermediate host for Moniliformis moniliformis?
Cockroaches
Taenia taeniaeformis and Capillaria hepatica are parasites of what organ?
Liver
Taenia serialis is a parasite of which organ?
Connective tissue
Klossiella muris are parasites of which organ?
Kindeys
Hepatozoon muris is parasites within what cells?
Hepatic cells
