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Repro2 MT > MHT, SERM, TSEC > Flashcards

MHT, SERM, TSEC Flashcards

1
Q

What does MHT stand for?

A

Menopausal hormone tx

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2
Q

What 2 drug groups are part of MHT?

A

Estrogens and Progestins

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3
Q

List the estrogens of MHT:

A

Estradiol, Conjugated Estrogens, Esterfied Estrogens, Estropipate (generic)

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4
Q

What do estrogens dec? Inc?

A

Dec activity of: cholesterol, anti-thrombin III, osteoclasts

Inc activity of: clotting factors, platelet aggregation, Na/fluid retention, thyroid binding globule

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5
Q

Risks w/ estrogens?

A

Endometrial hyperplasia, DVT/PE/stroke, breast CA

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6
Q

List the Progestins:

A

Medroxyprogesterone (MPA), Methyltestosterone, Progesterone

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7
Q

What is the purpose of progestins?

A

To oppose estrogen’s neg side-effects (uterine CA)

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8
Q

When are Progestins not indicated?

A

In women who have no uterus

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9
Q

What is the SERM? What’s its indication? Risks?

A 
Ospemifene
Dyspareunia (painful intercourse)
Worsening hot flashes/sweating, inc stroke risk, endometrial thickening
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10
Q

What is Ospemifene’s MOA?

A

Selective estrogen R compound, estrogen agonist in vagina, anti-estrogenic in breast

Inc cell growth, secretions, dec pH, dec pain

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11
Q

What are the estrogen Rs?

A

Alpha and beta

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12
Q

What is the TSEC?

A

Bazedoxifene

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13
Q

What is Bazedoxifene’s indication?

A

Women w/ intact uterus, moderate-to-severe vasomotor sxs d/t menopause

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14
Q

Risks involved w/ TSECs?

A

It’s Bazedoxifene..

Stroke, worsening hot flashes

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15
Q

TSEC MOA?

A

It’s Bazedoxifene..

Ant in endometrium and breast, agonist in bone

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16
Q

What is the TSEC comprised of?

A

Bazedoxifene = SERM + CE (conjugated estrogens)

17
Q

What are the sxs of menopause?

A

UMRSHNIV
Urinary incontinence, mood/cognitive issues, reduced quality of life, sleep disturbances, hot lashes, night sweats, inc risk of osteopenia/perosis/fractures, vaginal dryness/dyspareunia

18
Q

What is the primary tx for menopause in a pt w/ a uterus? No uterus?

A

Estrogen + progestin

Just estrogen

19
Q

What is it my job to do as a physician when a woman comes to be w/ menopause sxs?

A

Offer tx options and RELAY THE RISKS INVOLVED

Repro2 MT (7 decks)

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