Antenatal & Perinatal Pharm Flashcards
What are the coriticosteroids? Which one is used and for what?
Betamethasone, Dexamethasone
Betamethasone to stimulate fetal lung maturation
Does Betamethasone act on MCRs? GCRs?
No
Yes (is very potent)
What gene targets does Betamethasone have?
Those for Alveolar T2 pneumocytes that make surfactant
What drugs are used to induce labor? What class of drugs are they?
Dinoprostone (PGE2 analog) and Oxytocin (pituitary hormone)
What drug is used to ripen/soften the cervix for uterine contractions? Wha’s its MOA?
Dinoprostone
EP Rs in the uterus > dilation of cervix and contraction of the uterus
What are the side effects of PGE2 analogs?
Abd cramping, diarrhea, pre-mature labor and birth
Activation of other smooth mm in the body
What drugs are used to delay labor? What classes are they? Which is most often used?
MgSO4 (Ca C ant) (MOST OFTEN)
Nifedipine ("")
Salbutamol (B-adrenergic R agonist)
Ritodrine ("")
Terbutaline ("")What are the side effects of MgSO4?
Myasthenia gravis
What’s MgSO4’s MOA?
Competitive inh at Ca channels
What’s Nifedipine’s MOA? SEs?
Ca C ant at voltage-gated L-channels > relaxation of uterine smooth m
Dizziness and hypotension in mother, shouldn’t be used in pts w/ cardiovascular dx
What are the risks w/ the B-adrenergic R agonists that delay labor?
Hyperglycemia, tachycardia, hypotension, hypokalemia
DON’T use in gestational DM
What drugs are used to manipulate a PDA (patent ductus arteriosus)?
Alprostadil (keep it open)
Indomethacin (close it)
What class is Alprostadil? What’s its MOA and SEs?
PGE1 substitute
Compliments PGE2 in maintaining PDA
Pyrexia (elevated temps)
What is pyrexia associated w/?
Elevated temp in those take Alprostadil
What’s the MOA of Indomethacin?
Inh uterine COX-1 enzyme blocking formation of downstream prostaglandins > PDA closure
