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Repro2 MT > CH22 FGT > Flashcards

CH22 FGT Flashcards

1
Q

What’s the difference between a Bartholin cyst and a Gartner duct cyst?

A

Location, Bartholin in vulvar area, Gartner duct on lateral walls of the vagina

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2
Q

What is DES? What’s it involved with?

A

Diethylstilbestrol
Development anomalies of the vagina
Clear cell carcinoma of the vagina

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3
Q

What’s the most common malignant cancer of the vagina?

A

Carcinoma spreading from the cervix > primary SCC of the vagina

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4
Q

What are the benign tumors of the vagina?

A

LSH
Leiomyomas
Stromal tumors (polyps)
Hemangiomas

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5
Q

What do E6 and E7 affect?

A

E6 -> TERT and p53

E7 -> p21 and RB

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6
Q

What are the TORCH infections?

A 
T: Toxoplasmosis
O (other): syphilis, gonorrhea, chlamydia, varicella, Hep B
R: Rubella (German measles)
C: Cytomegalovirus (CMV)
H: Herpes Simplex Virus (HSV)
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7
Q

What is Condyloma Acuminatum? What is it associated w/?

A

A genital wart in the vulvar area

HPV 6 & 11

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8
Q

What is the most common cause of dysfunctional bleeding?

A

Anovulatory Cycle

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9
Q

What does anovulatory mean?

A

Failure to ovulate

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10
Q

What is absent besides ovulation in anovulatory cycle?

A

Pogesterone d/t no corpus luteum (because there’s no ovulation)

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11
Q

What bugs cause acute endometritis?

A

Group A strep, Staph

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12
Q

What are the genetics associated w/ Endometriosis?

A

PTEN and ARID1A

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13
Q

What’s the specific genetic defect seen in Endometrial Hyperplasia?

A

PTEN inactivation

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14
Q

What morphologic distinction is seen in Endometrial Hyperplasia?

A

Increased gland:stroma ratio

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15
Q

What syndrome is PTEN associated w/? What is PTEN generally involved w/?

A

Cowdren syndrome

Endometrium pathology

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16
Q

What is the most common invasive CA of the FGT?

A

Carcinoma of the endometrium

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17
Q

What are the functional endometrail disorders?

A

Mayer-RKH Syndrome
Anovulatory cycle
Inadequate Luteal Phase

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18
Q

What are the orgs in cervicitis vs endometritis?

A

Cervicitis: lactobacilli

Endometritis: Group A Strep, Staph

19
Q

What are the 3 dev anomalies of the vagina?

A

Septate (double) Vagina (mullerian duct)
Vaginal Adenosis
Gartner Duct Cyst (wolfian/mesonephric)

20
Q

What virus is LSIL and HSIL associated w/?

A

HPV-16

21
Q

Carcinoma of the endometrium has how many types?

A

2 types (T1 and T2)

22
Q

How does one distinguish polypoid growths of endothelial stromal adenosarcoma from endometrial polyps?

A

Adenosarcoma responds to estrogen! Endometrial polyps don’t

23
Q

What’s the most common tumor in women? Malignant or benign? What’s it consist of?

A

Leiomyomas (fibroids)

Benign

Smooth m

24
Q

What is MED12 associated w/?

A

Tumors of the myometrium (leiomyomas and leiomyosarcomas)

25
Q

What are the different tumor groups of the Uterus and Endometrium?

A

Malignant Tumors of the Endometrium
Tumors of Endometrial Stroma
Tumors of the Myometrium

26
Q

What is the most common primary lesion of the fallopian tubes? Where do they arise from?

A

Paratubular cyst

Mullerian duct remnants

27
Q

Cystic follicles of the ovaries are?

A

Very common

28
Q

What are the 3 types of ovarian components ovarian tumors can arise from?

A 
Epithelium (and endometriosis)
Germ cells (pluripotent)
Stromal cells/Sex Cords
29
Q

What are the 3 main epithelial tumors of the ovary?

A

Serous
Mucinous
Endometroid

30
Q

What’s the most common malignant ovarian tumor?

A

Serous carcinoma

31
Q

What are psammoma bodies associated w/?

A

Serous epithelial tumors of the ovary

32
Q

What are the 4 Germ Cell tumors of the ovary?

A

Teratomas
Dysgerminomas
Yolk Sac Tumors
Choriocarcinomas

33
Q

What are the 3 categories of the ovarian germ cell teratomas?

A

Mature (benign) = Dermoid cysts
Immature (malignant)
Monodermal/highly specialized

34
Q

What can specialized teratomas cause?

A

Struma ovarii -> hyperthyroidism

Carcinoid -> carcinoid syndrome

35
Q

Which Germ Cell tumor involves a KIT mutation?

A

Dysgerminoma

36
Q

What’s the most common malignant Germ Cell tumor?

A

Dysgerminoma

37
Q

What do Yolk Sac tumors produce?

A

Inc alpha-fetoprotein

38
Q

What are Schiller-Dural bodies associated w/?

A

Yolk-sac tumors

39
Q

What germ cell tumors are associated w/ chorionic gonadotropin release?

A

Choriocarcinomas

40
Q

Which Sex Cord tumor is associated w/ Call-Exner bodies? What does it elaborate?

A

Granulosa Cell tumor

LOTS of estrogen and inhibin

41
Q

What’s the most common malignant sex cord tumor?

A

Granulosa cell tumor

42
Q

What tumor is associated w/ Reinke crystalloids?

A

Sex Cord Hilus Cell Tumors

43
Q

Where do Kruckenberg tumors arise from? What’s their signature morph?

A

GI carcinoma, invades bilaterally

Mucin-producing signet-ring CA cells

Repro2 MT (7 decks)

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