MHC Structure Flashcards
What does MHC1 contain
It’s an A chain made of 3 extra cellular domains a1,a2 and a3
What does MHC II contain?
It contains two chains, a and B
How many structures are there of MHC II
4
How many binding site does each MHC molecule have?
1
What needs to happen to MHC molecules to be recognised by T cells?
There needs to be cell to cell contact
What’s the first level of control?
A peptide needs to associate with a given MHC of the individual
What’s the second level of control?
Mature T cells need a T cell receptor that recognises the peptide associated with MHC
What do MHC I molecules do?
They bind peptides that enter the RER from the cytosol
How is it determined which particular peptide binds in MHC I
The sequence of amino acids on the peptide bindings floor
What does classical MHC I molecules present?
antigenic peptides to the TCRs of CD8’s T lymphocytes
In MHC II how is the peptide binding groove formed?
Its formed from a heterodimer of a1 and b1
What does classical MHC II molecules present?
It presents peptides to CD4’s T helper cells
How is the peptide binding groove formed?
Two A helices form a wall and 8 B pleated sheets form a floor
A human has how many MHC I and MHC II
6 MHC I
12 MHC II
Peptides associated with MHC I are recognised by what cells?
TC
