MHC I and II

Question 1

How do MHC I and II get to membrane?

Answer 1

MHC I and II pick up unique peptide sequences produced by proteasome or endoscopes and move them to cell membrane

Question 2

Where is MHC I found?

Answer 2

Present on all cells

Question 3

What does MHC I present?

Answer 3

Antigens derived from intracellular material that can be found in the cytosol (parts of own proteins, parts of viruses)

Question 4

What does MHC I activate?

Answer 4

CD8+ve Tc cells - will kill infected cell they got activated by

Question 5

Where is MHC II found?

Answer 5

On APCs (professional phagocytes) macrophages, dendritic cells etc

Question 6

WHt does MHC II present?

Answer 6

Presents antigens derived from extracellular material (bacteria, toxins) that has been taken up via phagocytosis

Question 7

What does MHC II activate?

Answer 7

CD4+ve Th cells

These will activate more macrophages and B cells to clean up infected surrounding of cell