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Medicinal chemistry > mevalonate pathways2 > Flashcards

mevalonate pathways2 Flashcards

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1
Q

potent inhibitor of phospholipase a2

A

manoalide

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2
Q

from cacospongia and ircinia sponges

A

scalarolide and scalarin

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3
Q

novel sesterpenoid with new carbon skeleton
from aspergillus sp
inhibitory against mptpb ( mycobacterium tuberculosis protein tyrosine phosphatase b)

A

asperterpenoid

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4
Q

from c30 squalene
complex cyclic structures
difficult to characterize
colorless, crystalline,mhigh melting point, opticaly active substances

A

triterpenoids

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5
Q

chemical test for triterpenoids

A

liebermann burchard reaction

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6
Q

positive result of liebermann burchard reaction

A

blue green color

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7
Q

structural classification of tripterpenoids

A

acyclic
tetracylic
pentacyclic

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8
Q

cytotoxic triterpenes in cucurbitaceace

bitter tasting and purgative

A

cucurbitacins

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9
Q

glycosides which even at low conc produce frothing in aq soln because they soap like and surfactant properties

A

saponins

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10
Q

use as arrow poisons

A

saponins

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11
Q

abundant in dicotyledon family

A

saponins

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12
Q

high amts of saponin 10%

A

quillaia bark

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13
Q

structures related to zingiberene and beta sesquiphellandrene

A

gamma bisabolene

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14
Q

aroma of ginger

A

gamma bisabolene

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15
Q

sci name of ginger

A

Zingiber officinale zingiberaceae

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16
Q

formed by quenching bisabolyl cation with water

A

alpha bisabolol

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17
Q

major component of matricaria or german chamomile

A

alpha bisabolol

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18
Q

sci name of german chamomile

A

matricaria chamomilla asteraceae

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19
Q

immediate precursor of bisabolol oxides

A

alpha bisabolol

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20
Q

anyimigraine agent in fever few

A

parthenolide

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21
Q

sci name of fever few

A

Tanacetum parthenium asteraceae

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22
Q

germacronolide

A

parthenolide

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23
Q

cytotoxic germacranolide from elephants foot

A

elephantopin

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24
Q

sci name of elephants

A

elephantopus elatus asteraceae

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25
Q

causes skin allergies

A

parthenin

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26
Q

pseudoguaianolide from parthenium hysterophorus

A

parthenin

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27
Q

highly troublesome weed in india

A

parthenium hysterophorus asteraceae

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28
Q

structures related to zingiberene and beta sesquiphellandrene

A

gamma bisabolene

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29
Q

aroma of ginger

A

gamma bisabolene

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30
Q

sci name of ginger

A

Zingiber officinale zingiberaceae

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31
Q

formed by quenching bisabolyl cation with water

A

alpha bisabolol

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32
Q

major component of matricaria or german chamomile

A

alpha bisabolol

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33
Q

sci name of german chamomile

A

matricaria chamomilla asteraceae

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34
Q

immediate precursor of bisabolol oxides

A

alpha bisabolol

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35
Q

anyimigraine agent in fever few

A

parthenolide

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36
Q

sci name of fever few

A

Tanacetum parthenium asteraceae

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37
Q

germacronolide

A

parthenolide

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38
Q

cytotoxic germacranolide from elephants foot

A

elephantopin

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39
Q

sci name of elephants

A

elephantopus elatus asteraceae

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40
Q

causes skin allergies

A

parthenin

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41
Q

pseudoguaianolide from parthenium hysterophorus

A

parthenin

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42
Q

highly troublesome weed in india

A

parthenium hysterophorus asteraceae

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43
Q

sapogenin of quillaia saponins

A

quillaic acid

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44
Q

quillaia saponin is from the bark of

A

quillaja saponaria rosaceae

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45
Q

used as emulsifying agEnt in the form of quillaia tincture

A

quillaia saponins

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46
Q

sapogenin for glycyrrhizin

A

glycyrrhetic acid

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47
Q

glycyrrhizin is from the root of

A

glycyrrhiza glabra fabaceae

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48
Q

50 to 150 times sweet as sucrose

A

glycyrrhizin

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49
Q

used to mask the bitter taste of drug, demulcent, mild expectorant

A

glycyrrhizin

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50
Q

inhibit enzymes that catalyze the conversion of prostaglandin and glucocorticoids into inactive molecules thus increasing prostaglandin

A

glycyrrhetic acid

51
Q

semi synthetic drug of glycyrrhetic acid

A

carbenoxolone sodium

52
Q

treatment of gastric and duodenal ulcers

A

carbenoxolone sodium

53
Q

sapogenin of aescin

A

protoaescigenin and barringtogenol

54
Q

sci name of horsechestnut

A

aesculus hippocastrum, hippocastanaceae

55
Q

used as anti- inflammatory and anti- bruising

from seeds of horsechestnut

A

aescin

56
Q

modified triterpenoids

A

limonoids, quassinoids, steroids

57
Q

tetranotriterpenoids

A

limonoids

58
Q

potent insect antifeeder

A

azadirachtin

59
Q

from seeds of neem tree

A

azadirachtin

60
Q

sci name of neem tree

A

azadirachtaindica meliaceae

61
Q

from simaroubaceae particularly quassia

A

quassinoids

62
Q

qussia wood

A

quassia amara simaroubaceae

63
Q

have cytotoxic antimalarial amoebicidal properties

A

quassin

64
Q

eudesmane compound with anthelmintic components of artemisia sp

A

alpha santonin

65
Q

use for removal of roundworms

A

alpha santonin

66
Q

from matricaria flowers

A

matricin

67
Q

degrades on heating and decarboxylation to azulene derivative

A

matricin

68
Q

azulene derivative responsible for the blue coloration of oil distilled from flowers

A

chamazulene

69
Q

from thapsia garganica

A

Thapsigargin

70
Q

guaianolide esterified with acid group

A

thapsigargin

71
Q

tumor promoter and potent activator of cells in inflammatory response

A

thapsigargin

72
Q

found in juniper berries

A

alpha cadinene

73
Q

sci name of juniper berries

A

juniperus communis cupressaceae

74
Q

derived from 10 carbon ring containing cis germanyl cation

A

alpha cadinene

75
Q

from amorpha 4 11 diene its immediate precursor artemisinic acid and dihydroartemisinic acid via oxidation and reduction process

A

artemisinin

76
Q

found in artemisia annua asteraceae

A

artemisinin

77
Q

found in hops

A

humulene and beta caryophyllene

78
Q

sci name of hops

A

humulus lupulus cannabaceae

79
Q

found in oils of cloves and cinnamom

A

beta caryophyllene

80
Q

sci name of clove and cinnamon

A

syzygium aromaticum myrtaceae

cinnamomum zeylanicum lauraceae

81
Q

dimeric sesquiterpene found in flower buds and seeds of cotton plant

A

gossypol

82
Q

male infertility agent

A

gossypol

83
Q

fungal toxins found in infected grain foodstuffs

A

trichothecenes

84
Q

trichothecenes is derived from

A

fusarium sp

85
Q

trichothecene contaminant

produced from less substituted trichothecene isotrichodermol by oxygenation rxns

A

deoxynivalenol or vomitoxin

86
Q

reduced form of geranylgeraniol

A

phytol

87
Q

part of vit k and e

A

phytol

88
Q

constitutes lipophilic side chain of chlorophylls

A

phytol

89
Q

from common yew and mixture of at least 11 compounds

A

taxine

90
Q

sci name of yew

A

Taxus baccata Taxaceae

91
Q

has 4 membered oxetane ring and a complex ester side chain which are essential for antitumour activity

A

taxol or paclitaxel

92
Q

other sources of taxol

A

Taxomyces adreanae

Pestalotiopsis microspora

93
Q

fungus isolated from inner bark of Taxus brevifolia

A

Taxomyces adreanae

94
Q

fungus from himalayan yew or taxus wallachiana

A

pestalotiopsis microspora

95
Q

taxane derivatives

A 
baccatin III
10 deacetylbaccatin III
10 deacetyltaxol
cephalomannine
10 deacetylcephalomannine
96
Q

has improved water solubility than taxol and used clinically against ovarian and breast cancer

A

docetaxel or taxotere

97
Q

side chin analogue of taxol

A

docetaxel or taxotere

98
Q

toxic diterpene esters

A

phorbol

99
Q

ester of phorbol

A

12 o myristoylphorbol 13 acetate

100
Q

from the latex of euphorbiaceae

A

phorbol

101
Q

from castor oil

A

casbene

102
Q

sci name of castor

A

Riccinus communis euphorbiaceae

103
Q

from plant of Stevia rebaudiana asteraceae

A

stevioside

104
Q

stevioside have linkages which confer to its intensely sweet tase. what are these linkages?

A

glucosyl ester

glucoside

105
Q

100 to 300 times sweet as sucrose and use as sweetening agent

A

stevioside

106
Q

major component of the resin fraction of turpentine from pines

A

abietic acid

107
Q

highly oxidized diterpene trilactones

A

ginkgolides

108
Q

active principles of Ginkgo biloba ginkgoaceae

A

Ginkgolides

109
Q

for peripheral and cerebrovascular circulation

A

ginkgolides

110
Q

against cerebral vascular disease and senile dementia

A

Ginkgolides

111
Q

partially degraded ginkgolide

A

bilobalide

112
Q

potent and selective antagonistic activity towards platelet activating factor

A

ginkgolides

113
Q

isolated from coleus forskohlii lamiaceae

A

forskolin

114
Q

plant used in indian traditional medicine with hypotensive and antispasmodic activities

A

coleus forskohlil lamiaceae

115
Q

potent stimulator of aldehyde cyclase activity and has cardiovascular and bronchospasmolytic effects

A

forskolin

116
Q

4 types of terpenoids

A

abietane diterpenoids
amphilectan
beyerane
briarane

117
Q

major diterpene from yew tree

A

paclitaxol

118
Q

major diterpene from sawada fungus

A

gibberellius- check in ppt

119
Q

major diterpene in coleus

A

forskolin

120
Q

major diterpene in stevia

A

stevioside

121
Q

major diterpene in ginkgo

A

ginkgolide

122
Q

from marine sponge Luffariella variabilis thorectidae

A

manoalide

123
Q

antibiotic agent against streptomyces pyrogenes and staphylacoccus aureus

A

manoalide

Medicinal chemistry (6 decks)

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