mevalonate pathways2 Flashcards
1
Q
potent inhibitor of phospholipase a2
A
manoalide
2
Q
from cacospongia and ircinia sponges
A
scalarolide and scalarin
3
Q
novel sesterpenoid with new carbon skeleton
from aspergillus sp
inhibitory against mptpb ( mycobacterium tuberculosis protein tyrosine phosphatase b)
A
asperterpenoid
4
Q
from c30 squalene
complex cyclic structures
difficult to characterize
colorless, crystalline,mhigh melting point, opticaly active substances
A
triterpenoids
5
Q
chemical test for triterpenoids
A
liebermann burchard reaction
6
Q
positive result of liebermann burchard reaction
A
blue green color
7
Q
structural classification of tripterpenoids
A
acyclic
tetracylic
pentacyclic
8
Q
cytotoxic triterpenes in cucurbitaceace
bitter tasting and purgative
A
cucurbitacins
9
Q
glycosides which even at low conc produce frothing in aq soln because they soap like and surfactant properties
A
saponins
10
Q
use as arrow poisons
A
saponins
11
Q
abundant in dicotyledon family
A
saponins
12
Q
high amts of saponin 10%
A
quillaia bark
13
Q
structures related to zingiberene and beta sesquiphellandrene
A
gamma bisabolene
14
Q
aroma of ginger
A
gamma bisabolene
15
Q
sci name of ginger
A
Zingiber officinale zingiberaceae
16
Q
formed by quenching bisabolyl cation with water
A
alpha bisabolol
17
Q
major component of matricaria or german chamomile
A
alpha bisabolol
18
Q
sci name of german chamomile
A
matricaria chamomilla asteraceae
19
Q
immediate precursor of bisabolol oxides
A
alpha bisabolol
20
Q
anyimigraine agent in fever few
A
parthenolide
21
Q
sci name of fever few
A
Tanacetum parthenium asteraceae
22
Q
germacronolide
A
parthenolide
23
Q
cytotoxic germacranolide from elephants foot
A
elephantopin
24
Q
sci name of elephants
A
elephantopus elatus asteraceae
25
causes skin allergies
parthenin
26
pseudoguaianolide from parthenium hysterophorus
parthenin
27
highly troublesome weed in india
parthenium hysterophorus asteraceae
28
structures related to zingiberene and beta sesquiphellandrene
gamma bisabolene
29
aroma of ginger
gamma bisabolene
30
sci name of ginger
Zingiber officinale zingiberaceae
31
formed by quenching bisabolyl cation with water
alpha bisabolol
32
major component of matricaria or german chamomile
alpha bisabolol
33
sci name of german chamomile
matricaria chamomilla asteraceae
34
immediate precursor of bisabolol oxides
alpha bisabolol
35
anyimigraine agent in fever few
parthenolide
36
sci name of fever few
Tanacetum parthenium asteraceae
37
germacronolide
parthenolide
38
cytotoxic germacranolide from elephants foot
elephantopin
39
sci name of elephants
elephantopus elatus asteraceae
40
causes skin allergies
parthenin
41
pseudoguaianolide from parthenium hysterophorus
parthenin
42
highly troublesome weed in india
parthenium hysterophorus asteraceae
43
sapogenin of quillaia saponins
quillaic acid
44
quillaia saponin is from the bark of
quillaja saponaria rosaceae
45
used as emulsifying agEnt in the form of quillaia tincture
quillaia saponins
46
sapogenin for glycyrrhizin
glycyrrhetic acid
47
glycyrrhizin is from the root of
glycyrrhiza glabra fabaceae
48
50 to 150 times sweet as sucrose
glycyrrhizin
49
used to mask the bitter taste of drug, demulcent, mild expectorant
glycyrrhizin
50
inhibit enzymes that catalyze the conversion of prostaglandin and glucocorticoids into inactive molecules thus increasing prostaglandin
glycyrrhetic acid
51
semi synthetic drug of glycyrrhetic acid
carbenoxolone sodium
52
treatment of gastric and duodenal ulcers
carbenoxolone sodium
53
sapogenin of aescin
protoaescigenin and barringtogenol
54
sci name of horsechestnut
aesculus hippocastrum, hippocastanaceae
55
used as anti- inflammatory and anti- bruising
| from seeds of horsechestnut
aescin
56
modified triterpenoids
limonoids, quassinoids, steroids
57
tetranotriterpenoids
limonoids
58
potent insect antifeeder
azadirachtin
59
from seeds of neem tree
azadirachtin
60
sci name of neem tree
azadirachtaindica meliaceae
61
from simaroubaceae particularly quassia
quassinoids
62
qussia wood
quassia amara simaroubaceae
63
have cytotoxic antimalarial amoebicidal properties
quassin
64
eudesmane compound with anthelmintic components of artemisia sp
alpha santonin
65
use for removal of roundworms
alpha santonin
66
from matricaria flowers
matricin
67
degrades on heating and decarboxylation to azulene derivative
matricin
68
azulene derivative responsible for the blue coloration of oil distilled from flowers
chamazulene
69
from thapsia garganica
Thapsigargin
70
guaianolide esterified with acid group
thapsigargin
71
tumor promoter and potent activator of cells in inflammatory response
thapsigargin
72
found in juniper berries
alpha cadinene
73
sci name of juniper berries
juniperus communis cupressaceae
74
derived from 10 carbon ring containing cis germanyl cation
alpha cadinene
75
from amorpha 4 11 diene its immediate precursor artemisinic acid and dihydroartemisinic acid via oxidation and reduction process
artemisinin
76
found in artemisia annua asteraceae
artemisinin
77
found in hops
humulene and beta caryophyllene
78
sci name of hops
humulus lupulus cannabaceae
79
found in oils of cloves and cinnamom
beta caryophyllene
80
sci name of clove and cinnamon
syzygium aromaticum myrtaceae
| cinnamomum zeylanicum lauraceae
81
dimeric sesquiterpene found in flower buds and seeds of cotton plant
gossypol
82
male infertility agent
gossypol
83
fungal toxins found in infected grain foodstuffs
trichothecenes
84
trichothecenes is derived from
fusarium sp
85
trichothecene contaminant
| produced from less substituted trichothecene isotrichodermol by oxygenation rxns
deoxynivalenol or vomitoxin
86
reduced form of geranylgeraniol
phytol
87
part of vit k and e
phytol
88
constitutes lipophilic side chain of chlorophylls
phytol
89
from common yew and mixture of at least 11 compounds
taxine
90
sci name of yew
Taxus baccata Taxaceae
91
has 4 membered oxetane ring and a complex ester side chain which are essential for antitumour activity
taxol or paclitaxel
92
other sources of taxol
Taxomyces adreanae
| Pestalotiopsis microspora
93
fungus isolated from inner bark of Taxus brevifolia
Taxomyces adreanae
94
fungus from himalayan yew or taxus wallachiana
pestalotiopsis microspora
95
taxane derivatives
```
baccatin III
10 deacetylbaccatin III
10 deacetyltaxol
cephalomannine
10 deacetylcephalomannine
```
96
has improved water solubility than taxol and used clinically against ovarian and breast cancer
docetaxel or taxotere
97
side chin analogue of taxol
docetaxel or taxotere
98
toxic diterpene esters
phorbol
99
ester of phorbol
12 o myristoylphorbol 13 acetate
100
from the latex of euphorbiaceae
phorbol
101
from castor oil
casbene
102
sci name of castor
Riccinus communis euphorbiaceae
103
from plant of Stevia rebaudiana asteraceae
stevioside
104
stevioside have linkages which confer to its intensely sweet tase. what are these linkages?
glucosyl ester
| glucoside
105
100 to 300 times sweet as sucrose and use as sweetening agent
stevioside
106
major component of the resin fraction of turpentine from pines
abietic acid
107
highly oxidized diterpene trilactones
ginkgolides
108
active principles of Ginkgo biloba ginkgoaceae
Ginkgolides
109
for peripheral and cerebrovascular circulation
ginkgolides
110
against cerebral vascular disease and senile dementia
Ginkgolides
111
partially degraded ginkgolide
bilobalide
112
potent and selective antagonistic activity towards platelet activating factor
ginkgolides
113
isolated from coleus forskohlii lamiaceae
forskolin
114
plant used in indian traditional medicine with hypotensive and antispasmodic activities
coleus forskohlil lamiaceae
115
potent stimulator of aldehyde cyclase activity and has cardiovascular and bronchospasmolytic effects
forskolin
116
4 types of terpenoids
abietane diterpenoids
amphilectan
beyerane
briarane
117
major diterpene from yew tree
paclitaxol
118
major diterpene from sawada fungus
gibberellius- check in ppt
119
major diterpene in coleus
forskolin
120
major diterpene in stevia
stevioside
121
major diterpene in ginkgo
ginkgolide
122
from marine sponge Luffariella variabilis thorectidae
manoalide
123
antibiotic agent against streptomyces pyrogenes and staphylacoccus aureus
manoalide
