Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Medicinal chemistry > mevalonate pathway 3 > Flashcards

mevalonate pathway 3 Flashcards

1
Q

ring system tant is more flexible

A

cis fused ring system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

typifies the fundamental structure of steroids

A

cholesterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

steroidal surface active agents and soap like properties with the ability to cause foaming and hemolyze blod cells.

A

steroidal saponins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

characteristic features of steroidal saponins

A

spiroketal at c22
sugar residues on 3 beta hydroxyl
common configuration at c22

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

strengthen weakened heart

A

cardioactive glycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

modified triterpenoids with tetracyclic ring of lanosterolbut lacking 3 methyl groups at c4 and c14

A

steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

two types of aglycone? which is more common?

A

bufadienolides-24c

cardenolides- most common, 23c

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

example of cardenolide

A

digitoxigenin- digitalis purpurea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

example of bufadienolide

A

hellebrigenin-helleborus niger

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

characteristic features of cardioactive glycosides

A

14 beta hydroxyl
cis fusion a/b and c/d
unsaturated lactone c17
sugar residues on 3 beta hydroxyl

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

precursor of hellebrigenin via 5 beta hydroxylation and c19 oxidation

A

bufalin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

bufadienolide that is found on the skin of toads

A

bufalin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

bufadienolide found in human eye that regulate atpase activity

A

19 norbufalin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

sterols in plants, fungi, and algae

A

phytosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

24 ethyl and 24 methyl analogues of cholesterol

A

sitosterol

campesterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

from soya beans

A

campesterol

sitosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

sci name for soya bean

A

glycine max fabaceae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

has trans delta 22 double bond

A

stigmasterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

predominant sterol in fungi

A

ergosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

has beta oriented 24 methyl, trans deltaa 22 double bond, and delta 7 unsaturation

A

ergosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

abundant sterol in brown algae

A

fucosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

has 24 ethylidene substituent

A

fucosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

against gram + bacteria

A

fusidic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

antibacterial agent against acremonium fusidioides

A

fusidic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
substrate for alkylation
lanosterol- fungi | cycloartenol-plants and algae
26
for absorption and utilization of calcium
vit d or sunshine vitamin
27
vitamin d3 aka
cholecalciferol
28
sterol metabolite formed in animals from 7 dehydrocholesterol by suns irradiation
cholecalciferol
29
immediate delta 5,7 precursor of cholesterol
7 dehydrocholesterol
30
vitamin d2
ergocalciferol
31
used as rodenticide
ergocalciferol
32
active form of vit d
calcitriol
33
use for chronic vitamin d deficiency
calcitriol
34
stimulates the absorption of calcium and phosphate in intestine and mobilization of calcium in bone
calcitriol
35
synthetic reduction of tachysterol
dihydrotachysterol
36
has moulting hormone that allows for larval development and metamorphosis
ecdysones
37
c24 steroidal acid that is secred by the gut to emulsify and encourage digestion
bile acids
38
means of degrading cholesterol in diet
bile acids
39
cholesterol lowering drugs
cholestyramine and cholestipol
40
treat hight coronary patients by binding to bile acids
cholestyramine | colestipol
41
examples of bile acids
chenodeoxycholic acid ursodeoxycholic acid dehydrocholic acid
42
characteristic features of bile acids
c24 cholane skeleton cis fusion a/b rings 5c carboxylic acid side chain 3 alpha and 7alpha hydrolysis
43
acts as detergents by their non polar steroid nucleus and polar side chain
bile acids
44
steroid hormones produced by adrenal cortex
corticosteroids/ adrenocortical hormones
45
contain pregnane c21 skeleton
corticosteroids
46
2 main groups of corticosteroids
glucocorticoids | mineralocorticoids
47
concerned with synthesis of carbohydrates from proteins and deposition of glycogen in the liver
glucocorticoids
48
glucocorticoids
steroids that play important role in inflammatory process
49
examples of glucocorticoids
hydrocortisone | corticosterone
50
used to dissolve cholesterol gallstones as an alternative to surgery
ursodeoxycholic acid
51
used after surgery to improve biliary damage
dehydrocholic acid
52
concerned with control of mineral balance
mineralocorticoids
53
active compounds promoting the retention of sodium and chloride and excretion of potassium
minerlocorticoids
54
examples of mineralocorticoids
aldosterone | desoxycorticosterone or cortexone
55
aka as progestin or gestogens
progestogen
56
female sex hormone concerned in preparing the uterus for pregnancy
progestogen
57
example of pregestogen
progesterone
58
pregestational steroid
progesterone
59
secreted by the corpus luteus following the release
progesterone
60
intermediate in the biosynthesis of corticosteroids
progesterone
61
dervied from cholesterol via prenenolone in the formation of cardioactive glycosides
progesterone
62
femAle sex hormone produced in the ovaries and placent during pregnancy
estroges\ estrogen
63
responsible for female sex characteristics
estrogens
64
control menstrual cycle
estrogen
65
isolated in the urine of women
estrogen
66
example of oestrogens
estradiol oestrone oestrol
67
catalyzes synthesis of estrogens
aromatase
68
treatment of breast cancer
aromatase
69
male sex hormone
androgens
70
secreted by the testes and responsible for male sex characteristics
androgens
71
androgens secondary physiological effect
stimulates bone growth and muscle | storage of protein

Medicinal chemistry (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions