Methylprednisolone

Question 1

Methylprednisolone Sodium Succinate Class

Answer 1

Corticosteroid, glucocorticoid, steroid, anti inflammatory

Question 2

Methylprednisolone MOA

Answer 2

Enters target cells and causes many complex reactions that are responsible for its anti- inflammatory and immunosuppressive effects; thought to stabilize cellular and intracellular membranes.

Question 3

Methylprednisolone Indications

Answer 3

• Reactive airway disease: Acute exacerbation of emphysema, chronic bronchitis, asthma
• Anaphylaxis
• Burns potentially involving the airway

Question 4

Methylprednisolone Contraindications

Answer 4

Preterm Infants

Question 5

Methylprednisolone Adverse Reactions

Answer 5

None from single dose

Question 6

Methylprednisolone Drug Interactions

Answer 6

None

Question 7

Methylprednisolone Adult Dosage

Answer 7

Reactive Airway Disease, Anaphylaxis, Burns Potentially Involving the Airway:
Usual dose 125 mg slow IV bolus (much larger doses can be used).

Question 8

Methylprednisolone Pediatric Dosage

Answer 8

Reactive Airway Disease, Anaphylaxis, Burns Potentially Involving the Airway:
2-4 mg/kg slow IV bolus

Question 9

Methylprednisolone Routes

Answer 9

IV bolus

Question 10

Methylprednisolone Onset

Answer 10

1 - 6 hours; dogmatic 6 hour time to onset of benefit has decreased markedly during the last few years

Question 11

Methylprednisolone Peak Effects

Answer 11

8 hours

Question 12

Methylprednisolone Duration

Answer 12

18-36 hours

Question 13

Methylprednisolone AZ Drug Box Minimum

Answer 13

250 mg