METHANOL

Question 1

Drowsiness and blurred vision, coupled with a history of antifreeze ingestion. Diagnosis?

Answer 1

methanol poisoning

Question 2

Drug of choice for ethylene glycol and methanol toxicity

Answer 2

Fomepizole

Question 3

mechanism of action of fomepizole?

Answer 3

competitive inhibitor of alcohol dehydrogenase

Question 4

glucuronosyltransferase Function and its reduced activity causes________?

Answer 4

metabolism of drugs

Gilbert’s syndrome

Question 5

Which drug acts on aldehyde dehydrogenase?

Answer 5

Disulfiram

Question 6

Which drug inhibits dihydrofolate reductase

Answer 6

methotrexate

Question 7

Which drug is a competitive inhibitor of gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex?

Answer 7

Flumazenil antagonises this receptor complex to counteract excessive sedation from benzodiazepines

Question 8

What cause blindness in methanol poisoning?

Answer 8

optic neuropathy caused by Formic acid

Question 9

MANAGEMENT OF METHANOL POISONING?

Answer 9

Management

1. fomepizole (competitive inhibitor of alcohol dehydrogenase) or ethanol
2. haemodialysis
3. cofactor therapy with folinic acid to reduce ophthalmological complications