Macrolides

Question 1

the mechanism of action of macrolides?

Answer 1

inhibition of the 50S subunit of ribosomes of bacteria.

Question 2

inhibition of the 30S subunit of ribosomes? which antibiotics use this MOA?

Answer 2

1) Tetracyclines such as doxycycline

2) Aminoglycosides, such as gentamicin.

Question 3

inhibiting DNA topoisomerases and DNA gyrases. Which antibiotic use this MOA?

Answer 3

Quinolones, i.e floxacins

Question 4

inhibiting the enzyme dihydrofolate reductase. Which antibiotics use this MOA?

Answer 4

Trimethoprim

Question 5

Inhibition of peptidoglycan synthesis . Which antibiotics use this MOA?

Answer 5

beta-lactams. This class includes penicillin derivatives, cephalosporins and carbapenems.