Metaplasia Flashcards
Metaplasia ?
Change of one type of cell to another of the SAME CLASS
What causes metaplasia
Chronic irritation/ infection
Vitamin A deficiency
Types of metaplasia
Connective tissue
Mesothelial
Endothelial
Tumor
Give me an example of epithelial metaplasia ?
Columnar epithelium into squamous due to chronic cholecystitis due to presence of stone
Transitional epithelium into squamous in ?
Urinary bladder due to hilharziasis(parasitic infections)
Pseudostratified columnar to squamous in?
Bronchitis due to smoking and infection
Change of type connective tissue to another type of connective tissue?
Connective tissue metaplasia
Give me an example of connective tissue metaplasia ?
Myositis ossificans which is change of fibrous tissue into bone/cartilage
Disordered cellular proliferation ?
Dysplasia
Characteristics of Dysplasia?
Phleomorphism( change in size/shape)
Loss of polarity orientation)
Hyper chromatic nuclei (deep basophilic staining)
Presence of mitosis
Fate of dysplasia ?
They are pre malignant which can progress into cancer