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Toxic > Metals > Flashcards

Metals Flashcards

1
Q

How is Li eliminated?

A

Renally

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2
Q

What is Li metabolized to?

A

No metabolism

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3
Q

Li follows what ion in the blood? What is the significance of this?

A

Na+

Means that anything that causes an increase in Na uptake will increase Li uptake (aldosterone)

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4
Q

What is the effect of Li on the thyroid?

A

Decreases the effect of TSH on the thyroid

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5
Q

What is the difference between acute and chronic Li overdose?

A 
Acute = more GI side effect and less likely to be lethal 
Chronic = more CNS effects, and more likely to be lethal
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6
Q

What is the effect of NSAIDs (except ASA) on Li levels?

A

Causes decreased renal perfusion, increases Li

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7
Q

What is the effect of diuretics on Li levels?

A

Decreases

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8
Q

What are the CNS s/sx of Li OD?

A 
tremors
hyperreflexia
hypertonmia
confusion
fasciulations
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9
Q

What is the classic renal side effect of Li use?

A

nephrogenic diabetes insipidus

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10
Q

What is the teratogenic effect on the heart in neonates in mothers taking Li?

A

Ebstein’s anomaly (atrialization of the right ventricle)

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11
Q

What are the chronic CNS s/sx that can develop from overuse of Li?

A

Parkinsonism

Cerebellar s/sx

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12
Q

How well do Li levels correspond to s/sx?

A

not very

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13
Q

What is the role of activated charcoal in Li overdose?

A

no use–will not bind metals

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14
Q

What are the indications for dialysis of Li OD?

A

moderate-severe neurotoxicity

Renal failure

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15
Q

What are the acute and chronic levels of Li that are an indication for dialysis?

A 
Acute = over 4 me/L
Chronic = over 2.5 meq/L
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16
Q

How do humans excrete excess Fe?

A

We cannot, only regulate the uptake

17
Q

What causes the initial GI s/sx of Fe overdose?

A

Locally corrosive effects

18
Q

What causes lactate production with Fe overdose?

A

HoTN

19
Q

What type of Fe is concerning with OD?

A

elemental Fe. therefore must convert to elemental Fe

20
Q

Describe stages I-V of Fe intoxication?

A

I = GI s/sx
II= silent
III = Shock, MOSF
IV and V = ROS damage and scarring

21
Q

What is the role of TIBC in the treatment of Fe intoxication?

A

None

Toxic (12 decks)

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