Metabolismul Glucidic Flashcards

1
Q

Care este cel mai important element de control al glicolizei?

A

Fosfofructokinaza 1

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2
Q

Care este cel mai puternic activator al fosfofructokinazei 1 si ce indica acesta la nivel hepatic?

A
  • fructozo-2,6 difosfat

- indica o concentratie crescuta a glucozei

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3
Q

De catre cine este inhibata fosfofructokinaza 1?

A

Nivele crescute de :
ATP
CITRINA

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4
Q

De cine este activata fosfofructokinaza 1?

A

AMP

Fructozo-2,6-difosfat

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5
Q

Care sunt enzimele care catalizeaza reactiile ireversibile din glicoliza?

A
  • HEXOKINAZA / GLUCOKINAZA
  • FOSFOFRUCTOKINAZA 1
  • PIRUVAT KINAZA
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6
Q

Care sunt reactiile ireversibile din glicoliza?

A
  1. glucoza - glucoza 6 fosfat (HEXOKINAZA, GLUCOKINAZA)
  2. fructozo-6 fosfat - frutcozo 1,6 - difosfat (FOSOFRUCTOKINAZA 2)
  3. fosfoenol piruvat - piruvat ( PIRUVAT KINAZA)
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7
Q

HEXOKINAZA (unde este prezenta si ce afinitate are fata de gluocza)

A

Prezenta in toate tesuturile.

Are afinitate mare pentru glucoza - Km mic

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8
Q

Glucokinaza

A

se gaseste in ficat si in celulele beta pancreatice

are un Km mare si o afinitate scazuta pentru glucoza

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