Metabolism I Flashcards
define Catabolic
large molecules break down into smaller ones
Is Catabolism exergonic and endergonic?
energy being released- exergonic
Anabolism also known as synthesis requires
energy input–endergonic
Define Anabolism
small molecules are made into larger and more complex molecules
How does Substrate limeted reaction regulate itself
regulation by changing [A], [B], [C] and [D
product inhibiton and feedback are two types
Substrate limited reaction is often a what inhibition
allosteric inhibition
Substrate-limited reaction is often at a highly
exergonic steps
,** feedback inhibition** is inhibited by
the final product
Homeostatsis
balancing the final product with the cell’s needs
When it comes to substrate limited reaction, product inhibition is inhibited by
an immediate product
Enzyme limited reaction is regulated by
modulating corresponding enzymes
At what step does Enzyme limited reaction happen?
rate-limiting steps
Changing enzyme availability increases or decreases the
rate of synthesis or degradation
Spatial organization also known as
compartmentalization
How can you change enzyme active in an enzyme limited reaction? Name 4
Allostery, reverasible covalent modification, reverasal binding, irreversible covalent modification,
Where does Allostery inhibitors often bind to?
often binding a place that is not the active site
What are the 4 levels of spatial organizations in enzymes
Seperate individual enzymes, multi0enzymes complex, substrate channeling, and mebrane-bound enzyme system
In terms of spatial organization, What can individal enzymes do
they have independent enzymatic reactions
in seperate individual enzymes, substrates and intermediaties
must diffuse
Multi-enzymes complex are enzymes that need to
diffuse and form complexs
For multi-enzyme complex, substrate and intermediates
do not need to diffuse
Substrate channeling is easy to
regulate coordinately
What does Substrate channeling do the enzyme reaction rate
boosts the reaction rate
Membrane bound enzyme system has
minimal diffusion and many are large complexes
the most common form of energy is
adenosine triphosphate (ATP
What is the metabolic pathway
The transformation of ingested food to energy and simple compounds, or the synthesis of complex molecules, is performed by a series of enzymatic reactions. Collectively, these enzymes, and their substrates and products
Glycolysis is
first pathway used to degrade sugars and it is located in the cytoplasm
pyruvate
a 3 carbon keto acid that is the final product of glycolysis
Monod-Wyman-Changeaux model
concerted change
