metabolism 8.1 Flashcards

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1
Q

Contrast metabolic chain reaction pathways with cyclical reaction pathways

A

Some are linear, for example glycolysis, and some are cyclic, for example the Krebs cycle

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2
Q

Outline one example of a competitive enzyme inhibitor and one example of a noncompetitive enzyme inhibitor. ​

A

competitive: succinate to fumarate with inhibtor malonate which binds to to the enzyme.

incompetitive: troise phosphate into pyruvate with inhibtor alanine

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3
Q

what is end product inhibiton?

A

when the end product of a metabollic pathway acts as a non competitive inhibitor for the initial reaction

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4
Q

Illustrate end-product inhibition of the threonine to isoleucine metabolic pathway.

A
  1. threonine undergoes a 5 stage reaction with the enzyme threonine dehydratase for stage 1 to form isoleucine.
  2. Isoleucine will then bind to threonine dehydratase as a non competitive inhibitor.
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5
Q

Outline the benefit of end-product inhibition.

A

End-product inhibition functions to ensure levels of an essential product are always tightly regulated

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6
Q

State the consequence of an increase in isoleucine concentration.

A

excess production of isoleucine inhibits further synthesis

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7
Q

State two methods for determining the rate of enzyme controlled reactions

A
  1. The time taken for a particular substrate to be used up
  2. The time taken for a specific product to be made
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