Metabolic syndrome in women with polycystic ovary syndrome TOG 2018

Question 1

What is metabolic syndrome?

Answer 1

Central obesity
HTN
Insulin resistence
Atherogenic dyslipidaemia

Question 2

How common is metabolic syndrome in those with PCOS?

Answer 2

33%

Question 3

What is the increases risk of CHD & stroke in:
- PCOS
- Metabolic syndrome

Answer 3

• PCOS Doubled
• Metabolic syndrome - 3-6 x more likely, 12% increased mortality

Not stats on PCOS & metabolic syndrome combined

Question 4

Per year how many women with PCOS convert to impaired glucose intolerance

Answer 4

16%
2% of those will develop T2DM per year

Question 5

How much more likely are women with PCOS likely to develop GDM?

Answer 5

54%

Question 6

How much more likely is obstructive sleep apnoea with PCOS?

Answer 6

30 fold

Question 7

Definition of metabolic syndrome - 5 factors

Answer 7

Question 8

How often to screen for metabolic syndrome in women with PCOS?

Answer 8

Cigarette smoking - every visit
Obesity (weight, BMI, waist circumference): every visit
BP: BMI <25: annually, BMI >25, every visit
Lipid profile: Normal - every 2 years, abnormal or >weight - annually
OGTT: All women every 2 years, women with RF annually

Question 9

Management

Answer 9

Lifestyle: Weight loss, regular exercise diet

Medical:
Insulin sensitising: Metformin, Inostiol
Anti-obesity: Orlistat, Liraglutide, statins

Weight loss surgery