Metabolic Bone Diseases: 1 Flashcards
Metabolic bone diseases
5
- Osteoporosis
- Paget disease of the bone
- Osteomalacia
- Rickets
- Renal osteodystrophy
- What is the most common bone disease in the US?
2. Osteoporosis PP?
- Most common metabolic bone disease in the US
- Imbalance of bone homeostasis
- Bone resorption (osteoclast activity) outpaces bone deposition (osteoblast activity)
Bone remodeling: Continuous process and regulated by 2 control loops. Describe these? 2
- Negative feedback loop
- Hormonal process that maintains calcium homeostasis - Stress on the skeleton
- Mechanical
- Gravitational
Describe the hormonal control of bone homeostasis with PTH
3 steps
- Decrease in plasma calcium
- Release of PTH from the parathyroid
- Kidney, bones, GI
Effects of PTH
- Kidney? 2
- Bone? 2
- GI tract? 1
- ↑ Ca resorption in the renal tubules
- Kidneys convert Vit D to it’s active form
- ↑ osteoclast activity
- Release Ca2+ and PO4-
- GI tract ↑ absorption of Ca2+, PO4-
What is responsible for bone reabsorption?
Osteoclast activity
Osteoclast activity
Stimulated by? 4
- PTH,
- Calcitonin,
- GF IL-6
- Lack of gonadal hormones
Osteoclast activity
Lack of gonadal hormones affects the body how? 2
- Increased activity, vigor and lifespan of clasts
2. Low estrogen increases IL-6
Osteoblast activity
- Affect bone matric how?
- How do osteoblasts change with age?
- Builders of bone matrix
2. Decreased number of osteoblasts with aging
Thyroid gland: can stimulate or inhibit osteoclast activity
- How would it increase?
- Decrease it?
- Hyperthyroidism
- Thyroid hormones can stimulate osteoclast activity - ↑ plasma calcium
- Thyroid gland releases calcitonin
Hormonal control of bone homeostasis with Ca? 3 steps
- Increased Ca2+
- Calcitonin released from the thyroid
- Kidney, bones, GI tract
Effects of calcitonin
- Kidney? 2
- Bones? 2
- GI? 1
- ↓Ca2+ absorption
- ↓PO4- absorption
- ↓ osteoclast activity
- ↓ release of Ca2+
- ↓ Ca2+ absorption
Risk factors (major categories) OP 9
- Age (≥ 50 years old)
- Gender (female)
- Race (white or Asian)
- Activity level (inactivity)
- Diet
- Hormonal
- Meds
- Family history
- Medical history
Dietary risk factors for OP? 3
- ETOH
- Tobacco
- Low calcium intake or altered ability to absorb
Hormonal risk factors for OP? 6
- Amenorrhea
- Late menarche
- Early menopause
- Post menopausal state
- Low testosterone
- Low estrogen
Medical conditions that may be associated with osteoporosis
9
- Rheumatologic conditions (Lupus, RA, others)
- Malabsorption syndromes
- Hypogonadism
- Hyperthyroidism
- Chronic kidney disease
- Chronic liver disease
- COPD
- Hyperthyroidism
- Neurologic disorders
Meds that put you at risk for OP?
12
- Heparin
- Warfarin +/-
- Cyclosporine
- Medroxyprogesterone acetate (Provera)
- Vitamin A
- Loop diuretics
- Chemotherapeutic drugs
- Antiseizure meds
- Proton pump inhibitors
- H2 Blockers
- Antidepressants (TCA’s and SSRI’s)
- Glucocorticoids (STEROIDS)
Mnemonic
OSTEOPOROSIS
12
- LOw calcium intake
- Seizure meds
- Thin build
- ETOH
- HypOgonadism
- Previous fracture
- ThyrOid excess
- Race (white, Asian)
- Other relatives with osteoporosis
- Steroids
- Inactivity
- Smoking
Prevention of osteoporosis
5
- Exercise (weight bearing and muscle strengthening)
- Appropriate vitamin D and calcium intake
- Cessation of tobacco use
- Avoidance of excessive alcohol intake
- Screening tests: Measure height, DXA
Standard test for the evaluation of bone mineral density?
DEXA (DXA) scan
DEXA scan: Max weight for the machine?
300 pounds (some newer machines support up to 400 pounds)
DEXA (DXA) scan indications
3
- Anyone currently being treated or considering pharmacologic therapy for osteoporosis
- Anyone not receiving therapy in whom evidence of bone loss would lead to treatment
- Screening for osteoporosis