Metabolic bone disease Flashcards
What do osteoblasts do?
Bone formation
What do osteoclasts do?
Bone resorption
What factor stimulates osteoclasts?
RANK ligand
What mineral metabolism are bones responsible for?
Calcium
What is Paget’s disease of bone?
Localised disorder of bone turnover
-Increased bone resorption followed by increased formation
Leads to disorganised bone = bigger, less compact, more vascular and more susceptible to deformity and AC
Cause of Paget’s disease?
SQSRMT loci
Environmental trigger
-Possible chronic infection within osteoclast
What are the symptoms of Paget’s disease?
> 40 with bone pain
Bone deformity
Excessive heat over the bone
Or by neuro complications such as nerve deafness (hearing loss)
What is the treatment of Page’s disease?
Dont treat if asymptomatic unless in skull
Dont treat based on raised alk phosphate alone
IV bisphosphonate therapy and one off IV zoledronic acid
What is Rickets and osteomalacia?
Severe Vitamin D or Ca deficiency = insufficient mineralisation
Rickets = child
Osteomalacia = adults when epiphyseal lines are closed
What is osteogenesis imperfecta?
Genetic disorder of connective tissue characterised by fragile bones from mild trauma
Defects in type 1 collagen
What are some key types of osteogenesis imperfecta?
Type 1 = mild
Type 11 = lethal by 1yo
Type 111 = progressive deforming with dysplasia and poor growth
Type IV = similar to type 1 but more severe
What are some other S+S of osteogenesis imperfecta?
Growth deficiency Defective tooth formation hearing loss Blue sclera Scoliosis Barrel chest Ligamentous laxity Easy brusing
What is the management of osteogenesis imperfecta?
Surgical = treat fractures Medical = prevent fractures (IV bisphosphonates)
What is osteoperosis?
Metabolic bone disease characterised by low bone mass and deterioration of bone tissue = increased fracture risk
What do you use to scan for osteoperosis?
DEXA scan
