Metabolic And Genetic Disease (lab) Flashcards
How to evaluate patient evaluation and diagnosis
- History ( chief complain, medical and dental history )
- Radiograph
- Clinical examination
- Histopathology examination (biopsy result)
- LABORATORY EXAMINATION
- Blood test (CBC, WBC differentials, PT/PTT, clotting time, bleeding time)
- Hormone-specific test
- Biomarkers
Chronic, slowly progressive metabolic disorder of bone of undetermined cause
Paget’s disease
Hyperactive bone turnover state
Patients older than 50 years
Paget’s disease (osteitis deformans)
Etiology of paget’s disease
Unknown
Familial of paget’s disease
SQSTM1
Three phase of paget’s disease
Initial resorptive phase
Vascular phase
Sclerosing or osteoblastic phase
Phase of paegt’s disease
- overactive osteoclastic bone
- urinary calcium and hydroxyproline
Initial resorptive phase
Phae of paget’s disease
- replacement with vascularized connective tissue
Vascular phase
Phase of paget’s disease
- elevated alkaline phosphatase
Sclerosing or osteoblastic phase
Bone pain is deep and aching
Neurologic complainst
10-20% of patients are asymptomatic and diagnosed after radiographic or laboratory studies
Paget’s disease
Osteoclastic activity
Paget’s disease
Treatment of paget’s disease
Calcitonin and bisphosphonates
Alkaline phosphatase marker and urinary hydroxyproline 50% decrease if a good therapeutic response
Three types of hyperparathyroidism
Primary
Secondary
Hereditary
Type of hyperparathyroidism
Hyperplastic parathyroid glands
Parathyroid adenoma
Adenocarcinoma
Primary hyperparathyroidism
Type of hyperparathyroidism
Compensatory hyperplasia
Secnodary hyperparathyroidism