Mental Health Flashcards
Depression definition
• Mental state characterised by persistent low mood, loss of interest and enjoyment in everyday activities, neurovegetaive disturbance and reduced energy causing varying levels of social and occupational dysfunctional
how common is depression
leading cause of disability worldwide
who does depression affect
- Higher rates in older people
- Mid 30s if recurrent, can occur at any age
- F:M 2:1
- Also people of low social class and unemployment
causes of depression
• Abnormal concentrations of neurotransmitters, dysregulation of the HPA acis and abnormalities of second messenger systems have all been identified as being possibly involved in the pathophysiology of depression
risk factors of depression
- Age >65yrs
- Postnatal status
- Personal or family history of depressive disorder or suicide
- Corticosteroids
- Interferon
- Propanolol
- Oral contraceptives
- Co-existing
symptoms / signs of depression
- Presence of risk factors
- Depressed mood
- Anhedonia – diminished interest or pleasure in all or almost all activities most of the day
- Functional impairment
- Low energy
- Libido changes
- Sleep disturbance
- Excessive guilt
- Poor concentration
- Suicidal ideation
DDx of depression
- Adjustment disorder with depressed mood
- Substance/medication or medical illness-associaed and other depressive disorders
- Bipolar disorder
- PMDD – premenstrual dysphoric disorder
- Grief reaction
- Dementia
- Anxiety disorders
- Alcohol abuse
- Anorexia nervosa
Investigations of depression
• 1st LINE:
- Major depression - >5 of the following symptoms have been present during the same 2-week period and represent a change from previous functioning
- Metabolic panel – provides baseline and may reveal metabolic disturbance
- FBC – other causes of fatigue such as anaemia should be ruled out
- TFTs – an elevated serum TSH level suggests hypothyroidism
- PHQ9 & PHQ2 – patient health questionnaire – positive result screens for depression in primary care
Management of depression
• 1st LINE:
- SEVERE: psychiatric referral + hospitalisation + antidepressant e.g. citalopram (1st), agomelatine (2nd)
- MODERATE: antidepressant e.g. citalopram (1st), agomelatine (2nd)
- MILD: antidepressant e.g. citalopram (1st), agomelatine (2nd)
prognosis and complications of depression
prognosis:
• Complete remission of symptoms and return to normal functioning are the therapy goals
• Depression recurs in about one third of patients within 1 year of discontinuing treatment and in more than 50% of pts during their lifetime
complications:
• Sexual adverse effects of SSRIS and SNRIS
• Riskof self-injurious behaviour
• Undesired weight gain from antidepressants
• Unmasking mania
• Mania due to antidepressant withdrawal
Definition of Anxiety (Generalised Anxiety Disorder)
• Defined as at least 6 months of excessive worry about everyday issues that is disproportionate to any inherent risk, causing distress or impairment
How common is Anxiety (Generalised Anxiety Disorder)
• Usually occurs with other mental disorders – 76% of people who had more than 1 mental disorder for 12 months had GAD
- affects anyone of any age
Causes of Anxiety (Generalised Anxiety Disorder)
- Pathophysiology is not clearly understood but biological studies have focused on abnormal responses to stress, multiple neurotransmitter involvement, neurohormone alterations, sleep disturbances and genetic factors
- Abnormalities in brain corticotrophin-releasing factor secretion in the HPA axis appear to co-occur with anxiety episodes and may adversely affect neurotransmitters and arousal
Risk factors for Anxiety (Generalised Anxiety Disorder)
- Fx of anxiety
- Physical or emotional stress
- Hx of physical or emotional trauma
- Other anxiety disorder
- Female
Symptoms/signs for Anxiety (Generalised Anxiety Disorder)
- Presence of risk factors
- Excessive worry for at least 6 months
- Anxiety not confined to another mental disorder
- Anxiety not due to medication or substance
- Muscle tension
- Sleep disturbance
- Fatigue
- Restlessness
- Irritability
- Poor concentration
DDx for Anxiety (Generalised Anxiety Disorder)
- OCD
- Panic disorder
- Social phobia
- PTSD
- Somatoform disorders
- Depression
Investigations for Anxiety (Generalised Anxiety Disorder)
• 1st LINE:
- CLINICAL DIAGNOSIS: DSM-5 criteria for GAD are defined as at least 6 months of excesive worry about everyday issues that is disproportionate to any inherent risk, causing distress or impairment, worry is not confined to features of another mental disorder or as a result of substance abuse or a general medical condition
o At lest 3 of the following symptoms are present most of the time: restlessness, nervousness, being easily fatigued, poor concentration, irritability, muscle tension or sleep disturbance
management for Anxiety (Generalised Anxiety Disorder)
• 1st LINE:
- CBT - significant depression not responding to CBT or CT warrants a trial of an antidepressant if tolerated by the pt – suitable first-line option to pharmacotherapy
- SSRIs – e.g. citalopram
• 2nd LINE:
- Tricyclic antidepressant – e.g. imipramine or diazepam or pregablin
• With pregnant pts CBT (1st line), pharmacotherapy (2nd line) – be cautious with pharmacotherapy particularly for patients in their second or third trimester consult psychiatrist with experience in treating pregnant women or obstetrician when selecting the most appropriate drug to use in these pts
Prognosis and complications for Anxiety (Generalised Anxiety Disorder)
Prognosis - Depression co-occurs in 30 to 60% of pts and increases the risk for suicidality
Complications - Comorbid depression, substance abuse, dependence or anxiety disorder
Alcohol Dependance Definitions
• Alcohol use disorder is a term used to refer to the misuse of alcohol
how common is Alcohol dependance
- Common psychiatric disorder with lifetime prevalence estimates of 7% to 10% in most western countries
- Greatest in resource-poor countries, mainly adults
Causes of alcohol dependance
• Confirm the diagnosis using ICD-10 criteria for alcohol dependence. According to this, dependence is diagnosed if three or more of the following have been present together during the previous year:
- A strong desire or sense of compulsion to drink alcohol
- Difficulty in controlling drinking in terms of its onset, termination, or level of use
- A physiological withdrawal state when drinking has ceased or reduced, or drinking to relieve or avoid such a withdrawal state
- These symptoms include tremor, sweating, tachycardia, anxiety, insomnia, and less commonly seizures, disorientation and hallucinations
risk factors for alcohol dependance
- Fx of alcoholism
- Antisocial behaviour (pre-morbid)
- High trait anxiety level
symptoms/signs for alcohol dependance
- Presence of risk factors
- Withdrawal
- Tolerance
- Increased/decreased liver size, jaundice, ascites
DDx for alcohol dependance
- Other psychiatric disorders
* Other substance use disorders (especially sedatives)
Investigations for alcohol dependance
• 1st LINE:
- Diagnostic interview: uses the DMS-5 or ICD-20 cirteria to make a diagnosis of alcohol-use disorder presence of at least 2 of the 11 DSM-5 criteria over the same 12-month period indicates an alcohol use disorder
- Alcohol level (breath and blood)
- Clinical institute withdrawal assessment for alchol-revised (CIWA-Ar)
- CDT (carbohydrate-deficient transferrin) – increased concentrations found in serum after regular, excessive alcohol intake