Antibiotics Flashcards

1
Q

Chronic bronchitis common organisms

A

H. Influenza, moraxella, S. pneumoniae

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2
Q

Chronic bronchitis antibiotics

A

Amoxicillin/ clarithromycin

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3
Q

Uncomplicated community aquired pneumonia organisms

A

H.influenza, S.pneumoniae

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4
Q

Uncomplicated community aquired pneumonia antibiotics

A

Amoxicillin/ doxycycline/ clarithromycin

Staph suspect: flucloxacillin

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5
Q

Pneumonia due to atypical agents organisms

A

Chlamydia pneumoniae, Mycoplasma

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6
Q

Pneumonia due to atypical agents antibitoics

A

Clarithromycin

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7
Q

Hospital aquired pneumonia organisms

A

Pseudomonas, klebsiella, MRSA

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8
Q

Hospital aquired pneumonia antibiotics

A

<5d: co-amoxicav, cefuroxime

>5d: piptazo, Ceptazidime, Ciprofloxacin, Vancomycin

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9
Q

Urinary tract infections organisms

A

E.coli (70-95%)
Klebsiella
S.saprophyticus
Proteus

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10
Q

Uncomplicated lower UTI antibiotics

A

Sulfamethoxazole + trimethoprim

Nitrofurantoin

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11
Q

Uncomplicated pyelonephritis antibiotcs

A

Ciprofloxacin

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12
Q

Impetigo organisms

A

S. Pyogenes, S. Aureus

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13
Q

Cellulitis organisms

A

S.pyogenes, S.aureus

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14
Q

Impeitgo antibiotics

A

Tooical fusidic acid, flucloxacillin, erythomycin

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15
Q

Cellulitis antibitoics

A

Flucoxacillin, clarythomycin, erythromycin, doxycyline

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16
Q

Erysipelas organisms

A

Group A strep

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17
Q

Erysipelas antibiotics

A

Flucloxacillin, clarythromycin, erythromycin, doxycycline

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18
Q

Throat infection organism

A

Mostly S.pyogenes

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19
Q

Throat infection antibiotics

A

Phenoxymethyl penicillin, erythromycin

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20
Q

Sinusitis organisms

A

S. Pneumoniae, H.influenza, moraxella, S.Pyogenes

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21
Q

Sinusitis antibiotics

A

Amoxicillin, erythomycin, doxycycline

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22
Q

Otitis media organisms

A

S.pneumoniae, H.influenza, Moraxella

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23
Q

Otitis media antibiotics

A

Amoxicillin, erythromycin

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24
Q

Otitis externa organisms

A

P.aeruginosa, s.aureus

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25
Otitis externa antibiotics
Flucoxacillin, erythromycin
26
Gonorrhea antibiotics
IM Ceftriaxone, Oral Azithromycin
27
Chlamydia antibiotics
Doxycycline, azithromycin
28
Syphillis antibiotics
Benzathine Benzylpenicillin, Doxycycline, Erythomycin
29
Bacterial vaginosis antibitoics
Metronidazole, topical clindamycin
30
PID antibiotics
Oral Ofloxacin + oral metronidazole, or IM Ceftriaxone + Oral Doxycycline + Oral Metronidazole
31
C. Diff or Clostridium Difficile antibiotics
Metronidazole (if mild and first instance) | Vancomycin
32
Campylobacter antibiotics
Clarithromycin
33
Non-thyphoid salmonella
Ciprofloxacin
34
Bacterial meningitid organisms
S.Pneumoniae, N.meningitidis, H.influenza, MRSA
35
Bacterial meningitis antibiotics
Ceftriaxone, vancomycin, linezolid, ciprofloxacin, meropenem
36
Examples of aminoglycosides
Streptamycin, gentamycin,
37
Aminoglycoside mechanisms
Inhibit protein synthesis (bind 30s Ribosomal subunit)
38
Aminoglycosides cover
Gram negative + gram positive | Do not work on anaerobes
39
Side effects of aminoglycosides
Nephrotoxicity and ototoxicity
40
General indications for aminoglycosides
UTI, endocarditis, topical skin infections, pneumonia
41
Examples of cephalosporins
More brosd spectrum the further you go down 1. Cefazolin, 2. Cefotetan 3. cefotaxime, Ceftriaxone, Cefixime (oral) 4. Cefepime (with psudomonas cover) 5. Ceftaroline Ceftriaxone should not be given with calcium solutions, as it can cause calcium precipitations in the lungs and the kidneys
42
Mechanism of cephalosporins
Inhibit cell wall synthesis
43
Side effects of cephalosporins
Hypersensitivity and superinfection
44
Examples of carbapenems
Doripenem, impenem, meropenem
45
Carbapenems cover
Gram positve and gram negative
46
Carbapenems examples
Doripenem, Imipenem, Meropenem
47
Penicillins examples
Amoxicillin, Piperacillin, Flucloxacillin | Co-amoxiclav / Piptazo
48
Tetracyclines examples
tetracycline, doxycycline
49
quinolone examples
Ciprofloxacin, Levofloxacin, Moxifloxacin
50
Macrolides examples
Clarithromycin, erythromycin
51
Sulfonamides examples
Sulfamethoxazole, TMP
52
examples of glycopeptides
Vancomycin
53
carbapenems mechanism
inhibit cell wall synthesis
54
penicillin mechanism
inhibit cell wall synthesis
55
tetracyclines mechanism
inhibit protein synthesis
56
quinolones mechanism
inhibit DNA Gyrases
57
macrolides mechanism
inhibit protein synthesis (50s)
58
sulfonamides mechanism
inhibit folic acid
59
glycopeptides mechanism
inhibit cell wall synthesis (binds D-Ala - D-Ala terminal --> Transpeptidase inhibition
60
carbapenems side effects
GI upset rash allergy seizures in RF
61
penicillin side effects
hypersensitivity | neurotoxicity / seizures
62
tetracyclines side effects
GI, Renal and liver (reversible) toxicity Teeth staining impaired foetal bone growth
63
quinolones side effects
cartilage toxicity - archilles heel peripheral neuropathy pseudomembranous colitis
64
macrolides side effects
``` GI upset hypersensitivity jaundice QT prolongation CYP450 inhibition ```
65
sulphonamides side effects
``` Steven Johnson nephrotoxicity hyperkalaemia neutropenia kernicterus ```
66
glycopeptides side effects
nephrotoxicity ototoxicity hypotension + flushing (Red man syndrome)
67
carbapenems coverage
gram positive + gram negative
68
penicillins coverage
gram positive + gram negative
69
tetracyclines coverage
gram positive + gram negative | not staph/ strep generally
70
quinolones coverage
gram positive + gram negative
71
macrocodes coverage
mostly gram negative
72
sulphonamides coverage
gram positive + gram negative
73
glycopeptides coverage
gram positive (MRSA)
74
carbapenems indications
UTI Meningitis Sepsis Bone + Pelvis + Abdo infections
75
penicillins indications
endocarditis SSTI URTI / Pneumonia Neurosyphillis
76
tetracyclines indications
Anthrax C. Tetani Atypical CAP
77
quinolones indications
Resp: Atypical pneumonia UTI Gastroenteritis osteomyelitis
78
macrolides indications
resp/sinus/skin infections | chlamydia
79
sulfonamides indications
MRSA, | Cystitis due to E.coli
80
glycopeptides indications
MRSA Endocarditis Pseudomembranous colitis due to C.diff